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Acylation type determines ghrelin's effects on energy homeostasis in rodents.
Heppner KM, Chaudhary N, Müller TD, Kirchner H, Habegger KM, Ottaway N, Smiley DL, Dimarchi R, Hofmann SM, Woods SC, Sivertsen B, Holst B, Pfluger PT, Perez-Tilve D, Tschöp MH. Heppner KM, et al. Endocrinology. 2012 Oct;153(10):4687-95. doi: 10.1210/en.2012-1194. Epub 2012 Aug 3. Endocrinology. 2012. PMID: 22865372 Free PMC article.
Ghrelin action in the brain controls adipocyte metabolism.
Theander-Carrillo C, Wiedmer P, Cettour-Rose P, Nogueiras R, Perez-Tilve D, Pfluger P, Castaneda TR, Muzzin P, Schürmann A, Szanto I, Tschöp MH, Rohner-Jeanrenaud F. Theander-Carrillo C, et al. J Clin Invest. 2006 Jul;116(7):1983-93. doi: 10.1172/JCI25811. Epub 2006 Jun 8. J Clin Invest. 2006. PMID: 16767221 Free PMC article.
Effects of obestatin on energy balance and growth hormone secretion in rodents.
Nogueiras R, Pfluger P, Tovar S, Arnold M, Mitchell S, Morris A, Perez-Tilve D, Vázquez MJ, Wiedmer P, Castañeda TR, DiMarchi R, Tschöp M, Schurmann A, Joost HG, Williams LM, Langhans W, Diéguez C. Nogueiras R, et al. Endocrinology. 2007 Jan;148(1):21-6. doi: 10.1210/en.2006-0915. Epub 2006 Sep 28. Endocrinology. 2007. PMID: 17008393
The central melanocortin system directly controls peripheral lipid metabolism.
Nogueiras R, Wiedmer P, Perez-Tilve D, Veyrat-Durebex C, Keogh JM, Sutton GM, Pfluger PT, Castaneda TR, Neschen S, Hofmann SM, Howles PN, Morgan DA, Benoit SC, Szanto I, Schrott B, Schürmann A, Joost HG, Hammond C, Hui DY, Woods SC, Rahmouni K, Butler AA, Farooqi IS, O'Rahilly S, Rohner-Jeanrenaud F, Tschöp MH. Nogueiras R, et al. J Clin Invest. 2007 Nov;117(11):3475-88. doi: 10.1172/JCI31743. J Clin Invest. 2007. PMID: 17885689 Free PMC article.
The triple uptake inhibitor (1R,5S)-(+)-1-(3,4-dichlorophenyl)-3-azabicyclo[3.1.0] hexane hydrochloride (DOV 21947) reduces body weight and plasma triglycerides in rodent models of diet-induced obesity.
Tizzano JP, Stribling DS, Perez-Tilve D, Strack A, Frassetto A, Chen RZ, Fong TM, Shearman L, Krieter PA, Tschöp MH, Skolnick P, Basile AS. Tizzano JP, et al. J Pharmacol Exp Ther. 2008 Mar;324(3):1111-26. doi: 10.1124/jpet.107.133132. Epub 2007 Dec 18. J Pharmacol Exp Ther. 2008. PMID: 18089843
114 results