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G0/G1 switch gene-2 regulates human adipocyte lipolysis by affecting activity and localization of adipose triglyceride lipase.
Schweiger M, Paar M, Eder C, Brandis J, Moser E, Gorkiewicz G, Grond S, Radner FP, Cerk I, Cornaciu I, Oberer M, Kersten S, Zechner R, Zimmermann R, Lass A. Schweiger M, et al. Among authors: cerk i. J Lipid Res. 2012 Nov;53(11):2307-17. doi: 10.1194/jlr.M027409. Epub 2012 Aug 13. J Lipid Res. 2012. PMID: 22891293 Free PMC article.
Adipose Triglyceride Lipase Regulation: An Overview.
Cerk IK, Wechselberger L, Oberer M. Cerk IK, et al. Curr Protein Pept Sci. 2018;19(2):221-233. doi: 10.2174/1389203718666170918160110. Curr Protein Pept Sci. 2018. PMID: 28925902 Free PMC article. Review.
The minimal domain of adipose triglyceride lipase (ATGL) ranges until leucine 254 and can be activated and inhibited by CGI-58 and G0S2, respectively.
Cornaciu I, Boeszoermenyi A, Lindermuth H, Nagy HM, Cerk IK, Ebner C, Salzburger B, Gruber A, Schweiger M, Zechner R, Lass A, Zimmermann R, Oberer M. Cornaciu I, et al. Among authors: cerk ik. PLoS One. 2011;6(10):e26349. doi: 10.1371/journal.pone.0026349. Epub 2011 Oct 19. PLoS One. 2011. PMID: 22039468 Free PMC article.
G0/G1 Switch Gene 2 Regulates Cardiac Lipolysis.
Heier C, Radner FP, Moustafa T, Schreiber R, Grond S, Eichmann TO, Schweiger M, Schmidt A, Cerk IK, Oberer M, Theussl HC, Wojciechowski J, Penninger JM, Zimmermann R, Zechner R. Heier C, et al. Among authors: cerk ik. J Biol Chem. 2015 Oct 23;290(43):26141-50. doi: 10.1074/jbc.M115.671842. Epub 2015 Sep 8. J Biol Chem. 2015. PMID: 26350455 Free PMC article.
Residues of the minimal sequence of G0S2 collectively contribute to ATGL inhibition while C-and N-terminal extensions promote binding to ATGL.
Riegler-Berket L, Wechselberger L, Cerk IK, Padmanabha Das KM, Viertlmayr R, Kulminskaya N, Rodriguez Gamez CF, Schweiger M, Zechner R, Zimmermann R, Oberer M. Riegler-Berket L, et al. Among authors: cerk ik. Biochim Biophys Acta Mol Cell Biol Lipids. 2022 Mar;1867(3):159105. doi: 10.1016/j.bbalip.2021.159105. Epub 2022 Jan 10. Biochim Biophys Acta Mol Cell Biol Lipids. 2022. PMID: 35026402 Free article.