Tavares CD - Search Results

1

Targeted silencing of elongation factor 2 kinase suppresses growth and sensitizes tumors to doxorubicin in an orthotopic model of breast cancer.

Tekedereli I, Alpay SN, Tavares CD, Cobanoglu ZE, Kaoud TS, Sahin I, Sood AK, Lopez-Berestein G, Dalby KN, Ozpolat B. Tekedereli I, et al. Among authors: tavares cd. PLoS One. 2012;7(7):e41171. doi: 10.1371/journal.pone.0041171. Epub 2012 Jul 20. PLoS One. 2012. PMID: 22911754 Free PMC article.

2

Investigating the kinetic mechanism of inhibition of elongation factor 2 kinase by NH125: evidence of a common in vitro artifact.

Devkota AK, Tavares CD, Warthaka M, Abramczyk O, Marshall KD, Kaoud TS, Gorgulu K, Ozpolat B, Dalby KN. Devkota AK, et al. Among authors: tavares cd. Biochemistry. 2012 Mar 13;51(10):2100-12. doi: 10.1021/bi201787p. Epub 2012 Mar 5. Biochemistry. 2012. PMID: 22352903 Free PMC article.

3

Purification and characterization of tagless recombinant human elongation factor 2 kinase (eEF-2K) expressed in Escherichia coli.

Abramczyk O, Tavares CD, Devkota AK, Ryazanov AG, Turk BE, Riggs AF, Ozpolat B, Dalby KN. Abramczyk O, et al. Among authors: tavares cd. Protein Expr Purif. 2011 Oct;79(2):237-44. doi: 10.1016/j.pep.2011.05.005. Epub 2011 May 14. Protein Expr Purif. 2011. PMID: 21605678 Free PMC article.

4

Calcium/calmodulin stimulates the autophosphorylation of elongation factor 2 kinase on Thr-348 and Ser-500 to regulate its activity and calcium dependence.

Tavares CD, O'Brien JP, Abramczyk O, Devkota AK, Shores KS, Ferguson SB, Kaoud TS, Warthaka M, Marshall KD, Keller KM, Zhang Y, Brodbelt JS, Ozpolat B, Dalby KN. Tavares CD, et al. Biochemistry. 2012 Mar 20;51(11):2232-45. doi: 10.1021/bi201788e. Epub 2012 Mar 6. Biochemistry. 2012. PMID: 22329831 Free PMC article.

5

High-throughput screens for eEF-2 kinase.

Devkota AK, Warthaka M, Edupuganti R, Tavares CD, Johnson WH, Ozpolat B, Cho EJ, Dalby KN. Devkota AK, et al. Among authors: tavares cd. J Biomol Screen. 2014 Mar;19(3):445-52. doi: 10.1177/1087057113505204. Epub 2013 Sep 27. J Biomol Screen. 2014. PMID: 24078616

6

Application of Eukaryotic Elongation Factor-2 Kinase (eEF-2K) for Cancer Therapy: Expression, Purification, and High-Throughput Inhibitor Screening.

Tavares CD, Devkota AK, Dalby KN, Cho EJ. Tavares CD, et al. Methods Mol Biol. 2016;1360:19-33. doi: 10.1007/978-1-4939-3073-9_2. Methods Mol Biol. 2016. PMID: 26501899

7

Signal Integration at Elongation Factor 2 Kinase: THE ROLES OF CALCIUM, CALMODULIN, AND SER-500 PHOSPHORYLATION.

Tavares CDJ, Giles DH, Stancu G, Chitjian CA, Ferguson SB, Wellmann RM, Kaoud TS, Ghose R, Dalby KN. Tavares CDJ, et al. J Biol Chem. 2017 Feb 3;292(5):2032-2045. doi: 10.1074/jbc.M116.753277. Epub 2016 Dec 12. J Biol Chem. 2017. PMID: 27956550 Free PMC article.

8

Serotonin Analogues as Inhibitors of Breast Cancer Cell Growth.

Jose J, Tavares CDJ, Ebelt ND, Lodi A, Edupuganti R, Xie X, Devkota AK, Kaoud TS, Van Den Berg CL, Anslyn EV, Tiziani S, Bartholomeusz C, Dalby KN. Jose J, et al. ACS Med Chem Lett. 2017 Sep 14;8(10):1072-1076. doi: 10.1021/acsmedchemlett.7b00282. eCollection 2017 Oct 12. ACS Med Chem Lett. 2017. PMID: 29057053 Free PMC article.

9

The molecular mechanism of eukaryotic elongation factor 2 kinase activation.

Tavares CD, Ferguson SB, Giles DH, Wang Q, Wellmann RM, O'Brien JP, Warthaka M, Brodbelt JS, Ren P, Dalby KN. Tavares CD, et al. J Biol Chem. 2014 Aug 22;289(34):23901-16. doi: 10.1074/jbc.M114.577148. Epub 2014 Jul 10. J Biol Chem. 2014. PMID: 25012662 Free PMC article.

10

Structural Basis for the Recognition of Eukaryotic Elongation Factor 2 Kinase by Calmodulin.

Lee K, Alphonse S, Piserchio A, Tavares CD, Giles DH, Wellmann RM, Dalby KN, Ghose R. Lee K, et al. Among authors: tavares cd. Structure. 2016 Sep 6;24(9):1441-51. doi: 10.1016/j.str.2016.06.015. Epub 2016 Aug 4. Structure. 2016. PMID: 27499441 Free PMC article.

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