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Sorafenib has potent antitumor activity against multiple myeloma in vitro, ex vivo, and in vivo in the 5T33MM mouse model.
Kharaziha P, De Raeve H, Fristedt C, Li Q, Gruber A, Johnsson P, Kokaraki G, Panzar M, Laane E, Osterborg A, Zhivotovsky B, Jernberg-Wiklund H, Grandér D, Celsing F, Björkholm M, Vanderkerken K, Panaretakis T. Kharaziha P, et al. Among authors: osterborg a. Cancer Res. 2012 Oct 15;72(20):5348-62. doi: 10.1158/0008-5472.CAN-12-0658. Epub 2012 Sep 4. Cancer Res. 2012. PMID: 22952216
Treatment of multiple myeloma with interferon alpha: the Scandinavian experience.
Mellstedt H, Osterborg A, Björkholm M, Björeman M, Brenning G, Gahrton G, Grimfors G, Gyllenhammar H, Hast R, Juliusson G, et al. Mellstedt H, et al. Among authors: osterborg a. Br J Haematol. 1991 Oct;79 Suppl 1:21-5. doi: 10.1111/j.1365-2141.1991.tb08113.x. Br J Haematol. 1991. PMID: 1931703 Clinical Trial.
Alternating combination chemotherapy (VMCP/VBAP) is not superior to melphalan/prednisone in the treatment of multiple myeloma patients stage III--a randomized study from MGCS.
Osterborg A, Ahre A, Björkholm M, Björeman M, Brenning G, Gahrton G, Gyllenhammar H, Johansson B, Juliusson G, Järnmark M, et al. Osterborg A, et al. Eur J Haematol. 1989 Jul;43(1):54-62. doi: 10.1111/j.1600-0609.1989.tb01252.x. Eur J Haematol. 1989. PMID: 2670605 Clinical Trial.
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