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Neuropeptide Y (NPY): genetic variation in the human promoter alters glucocorticoid signaling, yielding increased NPY secretion and stress responses.
Zhang K, Rao F, Miramontes-Gonzalez JP, Hightower CM, Vaught B, Chen Y, Greenwood TA, Schork AJ, Wang L, Mahata M, Stridsberg M, Khandrika S, Biswas N, Fung MM, Waalen J, Middelberg RP, Heath AC, Montgomery GW, Martin NG, Whitfield JB, Baker DG, Schork NJ, Nievergelt CM, O'Connor DT. Zhang K, et al. Among authors: stridsberg m. J Am Coll Cardiol. 2012 Oct 23;60(17):1678-89. doi: 10.1016/j.jacc.2012.06.042. Epub 2012 Sep 26. J Am Coll Cardiol. 2012. PMID: 23021333 Free PMC article.
Naturally occurring human genetic variation in the 3'-untranslated region of the secretory protein chromogranin A is associated with autonomic blood pressure regulation and hypertension in a sex-dependent fashion.
Chen Y, Rao F, Rodriguez-Flores JL, Mahata M, Fung MM, Stridsberg M, Vaingankar SM, Wen G, Salem RM, Das M, Cockburn MG, Schork NJ, Ziegler MG, Hamilton BA, Mahata SK, Taupenot L, O'Connor DT. Chen Y, et al. Among authors: stridsberg m. J Am Coll Cardiol. 2008 Oct 28;52(18):1468-81. doi: 10.1016/j.jacc.2008.07.047. J Am Coll Cardiol. 2008. PMID: 19017515 Free PMC article.
Catecholamine release-inhibitory peptide catestatin (chromogranin A(352-372)): naturally occurring amino acid variant Gly364Ser causes profound changes in human autonomic activity and alters risk for hypertension.
Rao F, Wen G, Gayen JR, Das M, Vaingankar SM, Rana BK, Mahata M, Kennedy BP, Salem RM, Stridsberg M, Abel K, Smith DW, Eskin E, Schork NJ, Hamilton BA, Ziegler MG, Mahata SK, O'Connor DT. Rao F, et al. Among authors: stridsberg m. Circulation. 2007 May 1;115(17):2271-81. doi: 10.1161/CIRCULATIONAHA.106.628859. Epub 2007 Apr 16. Circulation. 2007. PMID: 17438154
An ancestral variant of Secretogranin II confers regulation by PHOX2 transcription factors and association with hypertension.
Wen G, Wessel J, Zhou W, Ehret GB, Rao F, Stridsberg M, Mahata SK, Gent PM, Das M, Cooper RS, Chakravarti A, Zhou H, Schork NJ, O'connor DT, Hamilton BA. Wen G, et al. Among authors: stridsberg m. Hum Mol Genet. 2007 Jul 15;16(14):1752-64. doi: 10.1093/hmg/ddm123. Epub 2007 Jun 21. Hum Mol Genet. 2007. PMID: 17584765 Free PMC article.
Chromogranin A polymorphisms are associated with hypertensive renal disease.
Salem RM, Cadman PE, Chen Y, Rao F, Wen G, Hamilton BA, Rana BK, Smith DW, Stridsberg M, Ward HJ, Mahata M, Mahata SK, Bowden DW, Hicks PJ, Freedman BI, Schork NJ, O'Connor DT. Salem RM, et al. Among authors: stridsberg m. J Am Soc Nephrol. 2008 Mar;19(3):600-14. doi: 10.1681/ASN.2007070754. Epub 2008 Jan 30. J Am Soc Nephrol. 2008. PMID: 18235090 Free PMC article.
Heritability and genome-wide linkage in US and australian twins identify novel genomic regions controlling chromogranin a: implications for secretion and blood pressure.
O'Connor DT, Zhu G, Rao F, Taupenot L, Fung MM, Das M, Mahata SK, Mahata M, Wang L, Zhang K, Greenwood TA, Shih PA, Cockburn MG, Ziegler MG, Stridsberg M, Martin NG, Whitfield JB. O'Connor DT, et al. Among authors: stridsberg m. Circulation. 2008 Jul 15;118(3):247-57. doi: 10.1161/CIRCULATIONAHA.107.709105. Epub 2008 Jun 30. Circulation. 2008. PMID: 18591442 Free PMC article.
Chromogranin A regulates renal function by triggering Weibel-Palade body exocytosis.
Chen Y, Mahata M, Rao F, Khandrika S, Courel M, Fung MM, Zhang K, Stridsberg M, Ziegler MG, Hamilton BA, Lipkowitz MS, Taupenot L, Nievergelt C, Mahata SK, O'Connor DT. Chen Y, et al. Among authors: stridsberg m. J Am Soc Nephrol. 2009 Jul;20(7):1623-32. doi: 10.1681/ASN.2008111148. Epub 2009 Jun 11. J Am Soc Nephrol. 2009. PMID: 19520754 Free PMC article.
241 results