Harrison I - Search Results

1

Prazosin, an α(1)-adrenoceptor antagonist, prevents memory deterioration in the APP23 transgenic mouse model of Alzheimer's disease.

Katsouri L, Vizcaychipi MP, McArthur S, Harrison I, Suárez-Calvet M, Lleo A, Lloyd DG, Ma D, Sastre M. Katsouri L, et al. Among authors: harrison i. Neurobiol Aging. 2013 Apr;34(4):1105-15. doi: 10.1016/j.neurobiolaging.2012.09.010. Epub 2012 Oct 11. Neurobiol Aging. 2013. PMID: 23063647

2

Imaging the accumulation and suppression of tau pathology using multiparametric MRI.

Holmes HE, Colgan N, Ismail O, Ma D, Powell NM, O'Callaghan JM, Harrison IF, Johnson RA, Murray TK, Ahmed Z, Heggenes M, Fisher A, Cardoso MJ, Modat M, Walker-Samuel S, Fisher EM, Ourselin S, O'Neill MJ, Wells JA, Collins EC, Lythgoe MF. Holmes HE, et al. Neurobiol Aging. 2016 Mar;39:184-94. doi: 10.1016/j.neurobiolaging.2015.12.001. Epub 2015 Dec 15. Neurobiol Aging. 2016. PMID: 26923415 Free PMC article.

3

Impaired glymphatic function and clearance of tau in an Alzheimer's disease model.

Harrison IF, Ismail O, Machhada A, Colgan N, Ohene Y, Nahavandi P, Ahmed Z, Fisher A, Meftah S, Murray TK, Ottersen OP, Nagelhus EA, O'Neill MJ, Wells JA, Lythgoe MF. Harrison IF, et al. Brain. 2020 Aug 1;143(8):2576-2593. doi: 10.1093/brain/awaa179. Brain. 2020. PMID: 32705145 Free PMC article.

4

An animal model mimicking pedunculopontine nucleus cholinergic degeneration in Parkinson's disease.

Pienaar IS, Harrison IF, Elson JL, Bury A, Woll P, Simon AK, Dexter DT. Pienaar IS, et al. Brain Struct Funct. 2015 Jan;220(1):479-500. doi: 10.1007/s00429-013-0669-5. Epub 2013 Nov 29. Brain Struct Funct. 2015. PMID: 24292256

5

The discovery of a highly selective 5,6,7,8-tetrahydrobenzo[4,5]thieno[2,3-d]pyrimidin-4(3H)-one SIRT2 inhibitor that is neuroprotective in an in vitro Parkinson's disease model.

Di Fruscia P, Zacharioudakis E, Liu C, Moniot S, Laohasinnarong S, Khongkow M, Harrison IF, Koltsida K, Reynolds CR, Schmidtkunz K, Jung M, Chapman KL, Steegborn C, Dexter DT, Sternberg MJ, Lam EW, Fuchter MJ. Di Fruscia P, et al. ChemMedChem. 2015 Jan;10(1):69-82. doi: 10.1002/cmdc.201402431. Epub 2014 Nov 13. ChemMedChem. 2015. PMID: 25395356

6

Neurorestoration induced by the HDAC inhibitor sodium valproate in the lactacystin model of Parkinson's is associated with histone acetylation and up-regulation of neurotrophic factors.

Harrison IF, Crum WR, Vernon AC, Dexter DT. Harrison IF, et al. Br J Pharmacol. 2015 Aug;172(16):4200-15. doi: 10.1111/bph.13208. Epub 2015 Jul 8. Br J Pharmacol. 2015. PMID: 26040297 Free PMC article.

7

Associated degeneration of ventral tegmental area dopaminergic neurons in the rat nigrostriatal lactacystin model of parkinsonism and their neuroprotection by valproate.

Harrison IF, Anis HK, Dexter DT. Harrison IF, et al. Neurosci Lett. 2016 Feb 12;614:16-23. doi: 10.1016/j.neulet.2015.12.052. Epub 2015 Dec 29. Neurosci Lett. 2016. PMID: 26742637 Free PMC article.

8

The histone deacetylase inhibitor nicotinamide exacerbates neurodegeneration in the lactacystin rat model of Parkinson's disease.

Harrison IF, Powell NM, Dexter DT. Harrison IF, et al. J Neurochem. 2019 Jan;148(1):136-156. doi: 10.1111/jnc.14599. Epub 2018 Nov 26. J Neurochem. 2019. PMID: 30269333 Free PMC article.

9

Optic nerve thinning and neurosensory retinal degeneration in the rTg4510 mouse model of frontotemporal dementia.

Harrison IF, Whitaker R, Bertelli PM, O'Callaghan JM, Csincsik L, Bocchetta M, Ma D, Fisher A, Ahmed Z, Murray TK, O'Neill MJ, Rohrer JD, Lythgoe MF, Lengyel I. Harrison IF, et al. Acta Neuropathol Commun. 2019 Jan 7;7(1):4. doi: 10.1186/s40478-018-0654-6. Acta Neuropathol Commun. 2019. PMID: 30616676 Free PMC article.

10

Glymphatic inhibition exacerbates tau propagation in an Alzheimer's disease model.

Lopes DM, Wells JA, Ma D, Wallis L, Park D, Llewellyn SK, Ahmed Z, Lythgoe MF, Harrison IF. Lopes DM, et al. Among authors: harrison if. Alzheimers Res Ther. 2024 Apr 5;16(1):71. doi: 10.1186/s13195-024-01439-2. Alzheimers Res Ther. 2024. PMID: 38576025 Free PMC article.

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