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Membrane localization is critical for activation of the PICK1 BAR domain.
Madsen KL, Eriksen J, Milan-Lobo L, Han DS, Niv MY, Ammendrup-Johnsen I, Henriksen U, Bhatia VK, Stamou D, Sitte HH, McMahon HT, Weinstein H, Gether U. Madsen KL, et al. Among authors: bhatia vk. Traffic. 2008 Aug;9(8):1327-43. doi: 10.1111/j.1600-0854.2008.00761.x. Epub 2008 May 8. Traffic. 2008. PMID: 18466293 Free PMC article.
Synapsin I senses membrane curvature by an amphipathic lipid packing sensor motif.
Krabben L, Fassio A, Bhatia VK, Pechstein A, Onofri F, Fadda M, Messa M, Rao Y, Shupliakov O, Stamou D, Benfenati F, Haucke V. Krabben L, et al. Among authors: bhatia vk. J Neurosci. 2011 Dec 7;31(49):18149-54. doi: 10.1523/JNEUROSCI.4345-11.2011. J Neurosci. 2011. PMID: 22159126 Free PMC article.
PICK1 deficiency impairs secretory vesicle biogenesis and leads to growth retardation and decreased glucose tolerance.
Holst B, Madsen KL, Jansen AM, Jin C, Rickhag M, Lund VK, Jensen M, Bhatia V, Sørensen G, Madsen AN, Xue Z, Møller SK, Woldbye D, Qvortrup K, Huganir R, Stamou D, Kjærulff O, Gether U. Holst B, et al. Among authors: bhatia v. PLoS Biol. 2013;11(4):e1001542. doi: 10.1371/journal.pbio.1001542. Epub 2013 Apr 23. PLoS Biol. 2013. PMID: 23630454 Free PMC article.
46 results