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Targeting the DNA-binding activity of the human ERG transcription factor using new heterocyclic dithiophene diamidines.
Nhili R, Peixoto P, Depauw S, Flajollet S, Dezitter X, Munde MM, Ismail MA, Kumar A, Farahat AA, Stephens CE, Duterque-Coquillaud M, David Wilson W, Boykin DW, David-Cordonnier MH. Nhili R, et al. Among authors: farahat aa. Nucleic Acids Res. 2013 Jan 7;41(1):125-38. doi: 10.1093/nar/gks971. Epub 2012 Oct 23. Nucleic Acids Res. 2013. PMID: 23093599 Free PMC article.
Synthesis and antiprotozoal activity of 2,5-bis[amidinoaryl]thiazoles.
Branowska D, Farahat AA, Kumar A, Wenzler T, Brun R, Liu Y, Wilson WD, Boykin DW. Branowska D, et al. Among authors: farahat aa. Bioorg Med Chem. 2010 May 15;18(10):3551-8. doi: 10.1016/j.bmc.2010.03.058. Epub 2010 Mar 27. Bioorg Med Chem. 2010. PMID: 20403703 Free PMC article.
Water-mediated binding of agents that target the DNA minor groove.
Liu Y, Kumar A, Depauw S, Nhili R, David-Cordonnier MH, Lee MP, Ismail MA, Farahat AA, Say M, Chackal-Catoen S, Batista-Parra A, Neidle S, Boykin DW, Wilson WD. Liu Y, et al. Among authors: farahat aa. J Am Chem Soc. 2011 Jul 6;133(26):10171-83. doi: 10.1021/ja202006u. Epub 2011 Jun 15. J Am Chem Soc. 2011. PMID: 21627167 Free PMC article.
The trypanocidal activity of amidine compounds does not correlate with their binding affinity to Trypanosoma cruzi kinetoplast DNA.
Daliry A, Pires MQ, Silva CF, Pacheco RS, Munde M, Stephens CE, Kumar A, Ismail MA, Liu Z, Farahat AA, Akay S, Som P, Hu Q, Boykin DW, Wilson WD, De Castro SL, Soeiro MN. Daliry A, et al. Among authors: farahat aa. Antimicrob Agents Chemother. 2011 Oct;55(10):4765-73. doi: 10.1128/AAC.00229-11. Epub 2011 Aug 1. Antimicrob Agents Chemother. 2011. PMID: 21807972 Free PMC article.
The efficacy of novel arylimidamides against Trypanosoma cruzi in vitro.
DA Silva CF, Daliry A, DA Silva PB, Akay S, Banerjee M, Farahat AA, Fisher MK, Hu L, Kumar A, Liu Z, Stephens CE, Boykin DW, Correia Soeiro MD. DA Silva CF, et al. Among authors: farahat aa. Parasitology. 2011 Dec;138(14):1863-9. doi: 10.1017/S0031182011001429. Epub 2011 Sep 9. Parasitology. 2011. PMID: 21902869
In vitro and in vivo investigation of the efficacy of arylimidamide DB1831 and its mesylated salt form--DB1965--against Trypanosoma cruzi infection.
da Silva CF, Batista Dda G, Oliveira GM, de Souza EM, Hammer ER, da Silva PB, Daliry A, Araujo JS, Britto C, Rodrigues AC, Liu Z, Farahat AA, Kumar A, Boykin DW, Soeiro Mde N. da Silva CF, et al. Among authors: farahat aa. PLoS One. 2012;7(1):e30356. doi: 10.1371/journal.pone.0030356. Epub 2012 Jan 23. PLoS One. 2012. PMID: 22291940 Free PMC article.
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