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TLR9-signaling is required for turning retinoic acid into a potent stimulator of RP105 (CD180)-mediated proliferation and IgG synthesis in human memory B cells.
Cell Immunol. 2012 Sep;279(1):87-95. doi: 10.1016/j.cellimm.2012.09.003. Epub 2012 Sep 19.
Cell Immunol. 2012.
PMID: 23103284
Retinoic acid improves defective TLR9/RP105-induced immune responses in common variable immunodeficiency-derived B cells.
Indrevær RL, Holm KL, Aukrust P, Osnes LT, Naderi EH, Fevang B, Blomhoff HK.
Indrevær RL, et al.
J Immunol. 2013 Oct 1;191(7):3624-33. doi: 10.4049/jimmunol.1300213. Epub 2013 Sep 4.
J Immunol. 2013.
PMID: 24006462
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IRF4 Is a Critical Gene in Retinoic Acid-Mediated Plasma Cell Formation and Is Deregulated in Common Variable Immunodeficiency-Derived B Cells.
Indrevær RL, Moskaug JØ, Paur I, Bøhn SK, Jørgensen SF, Blomhoff R, Aukrust P, Fevang B, Blomhoff HK.
Indrevær RL, et al.
J Immunol. 2015 Sep 15;195(6):2601-11. doi: 10.4049/jimmunol.1500250. Epub 2015 Aug 14.
J Immunol. 2015.
PMID: 26276871
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Myeloid cell leukaemia 1 has a vital role in retinoic acid-mediated protection of Toll-like receptor 9-stimulated B cells from spontaneous and DNA damage-induced apoptosis.
Holm KL, Indrevaer RL, Myklebust JH, Kolstad A, Moskaug JØ, Naderi EH, Blomhoff HK.
Holm KL, et al. Among authors: indrevaer rl.
Immunology. 2016 Sep;149(1):62-73. doi: 10.1111/imm.12629. Epub 2016 Jul 25.
Immunology. 2016.
PMID: 27278254
Free PMC article.
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TLR9 stimulation of B-cells induces transcription of p53 and prevents spontaneous and irradiation-induced cell death independent of DNA damage responses. Implications for Common variable immunodeficiency.
Holm KL, Syljuåsen RG, Hasvold G, Alsøe L, Nilsen H, Ivanauskiene K, Collas P, Shaposhnikov S, Collins A, Indrevær RL, Aukrust P, Fevang B, Blomhoff HK.
Holm KL, et al. Among authors: indrevaer rl.
PLoS One. 2017 Oct 3;12(10):e0185708. doi: 10.1371/journal.pone.0185708. eCollection 2017.
PLoS One. 2017.
PMID: 28973009
Free PMC article.
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