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The functional G143E variant of carboxylesterase 1 is associated with increased clopidogrel active metabolite levels and greater clopidogrel response.
Lewis JP, Horenstein RB, Ryan K, O'Connell JR, Gibson Q, Mitchell BD, Tanner K, Chai S, Bliden KP, Tantry US, Peer CJ, Figg WD, Spencer SD, Pacanowski MA, Gurbel PA, Shuldiner AR. Lewis JP, et al. Among authors: figg wd. Pharmacogenet Genomics. 2013 Jan;23(1):1-8. doi: 10.1097/FPC.0b013e32835aa8a2. Pharmacogenet Genomics. 2013. PMID: 23111421 Free PMC article.
A sensitive and rapid ultra HPLC-MS/MS method for the simultaneous detection of clopidogrel and its derivatized active thiol metabolite in human plasma.
Peer CJ, Spencer SD, VanDenBerg DA, Pacanowski MA, Horenstein RB, Figg WD. Peer CJ, et al. Among authors: figg wd. J Chromatogr B Analyt Technol Biomed Life Sci. 2012 Jan 1;880(1):132-9. doi: 10.1016/j.jchromb.2011.11.029. Epub 2011 Nov 26. J Chromatogr B Analyt Technol Biomed Life Sci. 2012. PMID: 22169056 Free PMC article.
Sorafenib is an inhibitor of UGT1A1 but is metabolized by UGT1A9: implications of genetic variants on pharmacokinetics and hyperbilirubinemia.
Peer CJ, Sissung TM, Kim A, Jain L, Woo S, Gardner ER, Kirkland CT, Troutman SM, English BC, Richardson ED, Federspiel J, Venzon D, Dahut W, Kohn E, Kummar S, Yarchoan R, Giaccone G, Widemann B, Figg WD. Peer CJ, et al. Among authors: figg wd. Clin Cancer Res. 2012 Apr 1;18(7):2099-107. doi: 10.1158/1078-0432.CCR-11-2484. Epub 2012 Feb 3. Clin Cancer Res. 2012. PMID: 22307138 Free PMC article.
Contribution of the OATP1B subfamily to cancer biology and treatment.
Sissung TM, Reece KM, Spencer S, Figg WD. Sissung TM, et al. Among authors: figg wd. Clin Pharmacol Ther. 2012 Nov;92(5):658-60. doi: 10.1038/clpt.2012.127. Epub 2012 Sep 26. Clin Pharmacol Ther. 2012. PMID: 23010650 Free PMC article. Review.
774 results