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Human SH2B1 mutations are associated with maladaptive behaviors and obesity.
Doche ME, Bochukova EG, Su HW, Pearce LR, Keogh JM, Henning E, Cline JM, Saeed S, Dale A, Cheetham T, Barroso I, Argetsinger LS, O'Rahilly S, Rui L, Carter-Su C, Farooqi IS. Doche ME, et al. Among authors: cline jm. J Clin Invest. 2012 Dec;122(12):4732-6. doi: 10.1172/JCI62696. Epub 2012 Nov 19. J Clin Invest. 2012. PMID: 23160192 Free PMC article.
Functional characterization of obesity-associated variants involving the α and β isoforms of human SH2B1.
Pearce LR, Joe R, Doche ME, Su HW, Keogh JM, Henning E, Argetsinger LS, Bochukova EG, Cline JM, Garg S, Saeed S, Shoelson S, O'Rahilly S, Barroso I, Rui L, Farooqi IS, Carter-Su C. Pearce LR, et al. Among authors: cline jm. Endocrinology. 2014 Sep;155(9):3219-26. doi: 10.1210/en.2014-1264. Epub 2014 Jun 27. Endocrinology. 2014. PMID: 24971614 Free PMC article.
Crucial Role of the SH2B1 PH Domain for the Control of Energy Balance.
Flores A, Argetsinger LS, Stadler LKJ, Malaga AE, Vander PB, DeSantis LC, Joe RM, Cline JM, Keogh JM, Henning E, Barroso I, Mendes de Oliveira E, Chandrashekar G, Clutter ES, Hu Y, Stuckey J, Farooqi IS, Myers MG Jr, Carter-Su C. Flores A, et al. Among authors: cline jm. Diabetes. 2019 Nov;68(11):2049-2062. doi: 10.2337/db19-0608. Epub 2019 Aug 22. Diabetes. 2019. PMID: 31439647 Free PMC article.
Structure-Activity Relationships of Natural and Semisynthetic Plecomacrolides Suggest Distinct Pathways for HIV-1 Immune Evasion and Vacuolar ATPase-Dependent Lysosomal Acidification.
McCauley M, Huston M, Condren AR, Pereira F, Cline J, Yaple-Maresh M, Painter MM, Zimmerman GE, Robertson AW, Carney N, Goodall C, Terry V, Müller R, Sherman DH, Collins KL. McCauley M, et al. J Med Chem. 2024 Mar 28;67(6):4483-4495. doi: 10.1021/acs.jmedchem.3c01574. Epub 2024 Mar 7. J Med Chem. 2024. PMID: 38452116 Free PMC article.
257 results