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Interleukin-33 drives a proinflammatory endothelial activation that selectively targets nonquiescent cells.
Pollheimer J, Bodin J, Sundnes O, Edelmann RJ, Skånland SS, Sponheim J, Brox MJ, Sundlisaeter E, Loos T, Vatn M, Kasprzycka M, Wang J, Küchler AM, Taskén K, Haraldsen G, Hol J. Pollheimer J, et al. Among authors: sundlisaeter e. Arterioscler Thromb Vasc Biol. 2013 Feb;33(2):e47-55. doi: 10.1161/ATVBAHA.112.253427. Epub 2012 Nov 15. Arterioscler Thromb Vasc Biol. 2013. PMID: 23162017
The alarmin IL-33 is a notch target in quiescent endothelial cells.
Sundlisaeter E, Edelmann RJ, Hol J, Sponheim J, Küchler AM, Weiss M, Udalova IA, Midwood KS, Kasprzycka M, Haraldsen G. Sundlisaeter E, et al. Am J Pathol. 2012 Sep;181(3):1099-111. doi: 10.1016/j.ajpath.2012.06.003. Epub 2012 Jul 16. Am J Pathol. 2012. PMID: 22809957
Inhibition of Endothelial NOTCH1 Signaling Attenuates Inflammation by Reducing Cytokine-Mediated Histone Acetylation at Inflammatory Enhancers.
Poulsen LC, Edelmann RJ, Krüger S, Diéguez-Hurtado R, Shah A, Stav-Noraas TE, Renzi A, Szymanska M, Wang J, Ehling M, Benedito R, Kasprzycka M, Bækkevold E, Sundnes O, Midwood KS, Scott H, Collas P, Siebel CW, Adams RH, Haraldsen G, Sundlisæter E, Hol J. Poulsen LC, et al. Among authors: sundlisaeter e. Arterioscler Thromb Vasc Biol. 2018 Apr;38(4):854-869. doi: 10.1161/ATVBAHA.117.310388. Epub 2018 Feb 15. Arterioscler Thromb Vasc Biol. 2018. PMID: 29449332
Targeting the Notch Signaling Pathway in Chronic Inflammatory Diseases.
Christopoulos PF, Gjølberg TT, Krüger S, Haraldsen G, Andersen JT, Sundlisæter E. Christopoulos PF, et al. Among authors: sundlisaeter e. Front Immunol. 2021 Apr 12;12:668207. doi: 10.3389/fimmu.2021.668207. eCollection 2021. Front Immunol. 2021. PMID: 33912195 Free PMC article. Review.
Antibody blockade of Jagged1 attenuates choroidal neovascularization.
Gjølberg TT, Wik JA, Johannessen H, Krüger S, Bassi N, Christopoulos PF, Bern M, Foss S, Petrovski G, Moe MC, Haraldsen G, Fosse JH, Skålhegg BS, Andersen JT, Sundlisæter E. Gjølberg TT, et al. Among authors: sundlisaeter e. Nat Commun. 2023 May 30;14(1):3109. doi: 10.1038/s41467-023-38563-w. Nat Commun. 2023. PMID: 37253747 Free PMC article.
Angiogenesis-independent tumor growth mediated by stem-like cancer cells.
Sakariassen PØ, Prestegarden L, Wang J, Skaftnesmo KO, Mahesparan R, Molthoff C, Sminia P, Sundlisaeter E, Misra A, Tysnes BB, Chekenya M, Peters H, Lende G, Kalland KH, Øyan AM, Petersen K, Jonassen I, van der Kogel A, Feuerstein BG, Terzis AJ, Bjerkvig R, Enger PØ. Sakariassen PØ, et al. Among authors: sundlisaeter e. Proc Natl Acad Sci U S A. 2006 Oct 31;103(44):16466-71. doi: 10.1073/pnas.0607668103. Epub 2006 Oct 20. Proc Natl Acad Sci U S A. 2006. PMID: 17056721 Free PMC article.
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