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Human adipose-derived mesenchymal stromal cells injected systemically into GRMD dogs without immunosuppression are able to reach the host muscle and express human dystrophin.
Vieira NM, Valadares M, Zucconi E, Secco M, Bueno CR Jr, Brandalise V, Assoni A, Gomes J, Landini V, Andrade T, Caetano HV, Vainzof M, Zatz M. Vieira NM, et al. Among authors: brandalise v. Cell Transplant. 2012;21(7):1407-17. doi: 10.3727/096368911X. Cell Transplant. 2012. PMID: 23168016 Free article.
SJL dystrophic mice express a significant amount of human muscle proteins following systemic delivery of human adipose-derived stromal cells without immunosuppression.
Vieira NM, Bueno CR Jr, Brandalise V, Moraes LV, Zucconi E, Secco M, Suzuki MF, Camargo MM, Bartolini P, Brum PC, Vainzof M, Zatz M. Vieira NM, et al. Among authors: brandalise v. Stem Cells. 2008 Sep;26(9):2391-8. doi: 10.1634/stemcells.2008-0043. Epub 2008 Jun 26. Stem Cells. 2008. PMID: 18583542