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Fumarate is cardioprotective via activation of the Nrf2 antioxidant pathway.
Ashrafian H, Czibik G, Bellahcene M, Aksentijević D, Smith AC, Mitchell SJ, Dodd MS, Kirwan J, Byrne JJ, Ludwig C, Isackson H, Yavari A, Støttrup NB, Contractor H, Cahill TJ, Sahgal N, Ball DR, Birkler RI, Hargreaves I, Tennant DA, Land J, Lygate CA, Johannsen M, Kharbanda RK, Neubauer S, Redwood C, de Cabo R, Ahmet I, Talan M, Günther UL, Robinson AJ, Viant MR, Pollard PJ, Tyler DJ, Watkins H. Ashrafian H, et al. Among authors: tennant da. Cell Metab. 2012 Mar 7;15(3):361-71. doi: 10.1016/j.cmet.2012.01.017. Cell Metab. 2012. PMID: 22405071 Free PMC article.
Metabolic plasticity in CLL: adaptation to the hypoxic niche.
Koczula KM, Ludwig C, Hayden R, Cronin L, Pratt G, Parry H, Tennant D, Drayson M, Bunce CM, Khanim FL, Günther UL. Koczula KM, et al. Leukemia. 2016 Jan;30(1):65-73. doi: 10.1038/leu.2015.187. Epub 2015 Jul 23. Leukemia. 2016. PMID: 26202928 Free PMC article.
Combined Analysis of NMR and MS Spectra (CANMS).
Chong M, Jayaraman A, Marin S, Selivanov V, de Atauri Carulla PR, Tennant DA, Cascante M, Günther UL, Ludwig C. Chong M, et al. Among authors: tennant da. Angew Chem Int Ed Engl. 2017 Apr 3;56(15):4140-4144. doi: 10.1002/anie.201611634. Epub 2017 Mar 8. Angew Chem Int Ed Engl. 2017. PMID: 28272839
Proline synthesis through PYCR1 is required to support cancer cell proliferation and survival in oxygen-limiting conditions.
Westbrook RL, Bridges E, Roberts J, Escribano-Gonzalez C, Eales KL, Vettore LA, Walker PD, Vera-Siguenza E, Rana H, Cuozzo F, Eskla KL, Vellama H, Shaaban A, Nixon C, Luuk H, Lavery GG, Hodson DJ, Harris AL, Tennant DA. Westbrook RL, et al. Among authors: tennant da. Cell Rep. 2022 Feb 1;38(5):110320. doi: 10.1016/j.celrep.2022.110320. Cell Rep. 2022. PMID: 35108535 Free PMC article.
PK-M2 Makes Cells Sweeter on HIF1.
Tennant DA. Tennant DA. Cell. 2011 May 27;145(5):647-9. doi: 10.1016/j.cell.2011.05.009. Cell. 2011. PMID: 21620132 Free article.
A role for cytosolic fumarate hydratase in urea cycle metabolism and renal neoplasia.
Adam J, Yang M, Bauerschmidt C, Kitagawa M, O'Flaherty L, Maheswaran P, Özkan G, Sahgal N, Baban D, Kato K, Saito K, Iino K, Igarashi K, Stratford M, Pugh C, Tennant DA, Ludwig C, Davies B, Ratcliffe PJ, El-Bahrawy M, Ashrafian H, Soga T, Pollard PJ. Adam J, et al. Among authors: tennant da. Cell Rep. 2013 May 30;3(5):1440-8. doi: 10.1016/j.celrep.2013.04.006. Epub 2013 May 2. Cell Rep. 2013. PMID: 23643539 Free PMC article.
Alterations in bone marrow metabolism are an early and consistent feature during the development of MGUS and multiple myeloma.
Ludwig C, Williams DS, Bartlett DB, Essex SJ, McNee G, Allwood JW, Jewell E, Barkhuisen A, Parry H, Anandram S, Nicolson P, Gardener C, Seymour F, Basu S, Dunn WB, Moss PA, Pratt G, Tennant DA. Ludwig C, et al. Among authors: tennant da. Blood Cancer J. 2015 Oct 16;5(10):e359. doi: 10.1038/bcj.2015.85. Blood Cancer J. 2015. PMID: 26473531 Free PMC article. No abstract available.
108 results