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The impact of partial and complete loss-of-function mutations in endothelial lipase on high-density lipoprotein levels and functionality in humans.
Singaraja RR, Sivapalaratnam S, Hovingh K, Dubé MP, Castro-Perez J, Collins HL, Adelman SJ, Riwanto M, Manz J, Hubbard B, Tietjen I, Wong K, Mitnaul LJ, van Heek M, Lin L, Roddy TA, McEwen J, Dallinge-Thie G, van Vark-van der Zee L, Verwoert G, Winther M, van Duijn C, Hofman A, Trip MD, Marais AD, Asztalos B, Landmesser U, Sijbrands E, Kastelein JJ, Hayden MR. Singaraja RR, et al. Among authors: sivapalaratnam s. Circ Cardiovasc Genet. 2013 Feb;6(1):54-62. doi: 10.1161/CIRCGENETICS.111.962613. Epub 2012 Dec 14. Circ Cardiovasc Genet. 2013. PMID: 23243195 Free article.
Low-density lipoprotein receptor mutations generate synthetic genome-wide associations.
Oosterveer DM, Versmissen J, Defesche JC, Sivapalaratnam S, Yazdanpanah M, Mulder M, van der Zee L, Uitterlinden AG, van Duijn CM, Hofman A, Kastelein JJ, Aulchenko YS, Sijbrands EJ. Oosterveer DM, et al. Among authors: sivapalaratnam s. Eur J Hum Genet. 2013 May;21(5):563-6. doi: 10.1038/ejhg.2012.207. Epub 2012 Sep 12. Eur J Hum Genet. 2013. PMID: 22968135 Free PMC article.
Monocyte gene expression signature of patients with early onset coronary artery disease.
Sivapalaratnam S, Basart H, Watkins NA, Maiwald S, Rendon A, Krishnan U, Sondermeijer BM, Creemers EE, Pinto-Sietsma SJ, Hovingh K, Ouwehand WH, Kastelein JJ, Goodall AH, Trip MD. Sivapalaratnam S, et al. PLoS One. 2012;7(2):e32166. doi: 10.1371/journal.pone.0032166. Epub 2012 Feb 21. PLoS One. 2012. PMID: 22363809 Free PMC article. Clinical Trial.
A rare variant in MCF2L identified using exclusion linkage in a pedigree with premature atherosclerosis.
Maiwald S, Motazacker MM, van Capelleveen JC, Sivapalaratnam S, van der Wal AC, van der Loos C, Kastelein JJ, Ouwehand WH, Hovingh GK, Trip MD, van Buul JD, Dallinga-Thie GM. Maiwald S, et al. Among authors: sivapalaratnam s. Eur J Hum Genet. 2016 Jan;24(1):86-91. doi: 10.1038/ejhg.2015.70. Epub 2015 Apr 22. Eur J Hum Genet. 2016. PMID: 25898923 Free PMC article.
Exome-wide association study of plasma lipids in >300,000 individuals.
Liu DJ, Peloso GM, Yu H, Butterworth AS, Wang X, Mahajan A, Saleheen D, Emdin C, Alam D, Alves AC, Amouyel P, Di Angelantonio E, Arveiler D, Assimes TL, Auer PL, Baber U, Ballantyne CM, Bang LE, Benn M, Bis JC, Boehnke M, Boerwinkle E, Bork-Jensen J, Bottinger EP, Brandslund I, Brown M, Busonero F, Caulfield MJ, Chambers JC, Chasman DI, Chen YE, Chen YI, Chowdhury R, Christensen C, Chu AY, Connell JM, Cucca F, Cupples LA, Damrauer SM, Davies G, Deary IJ, Dedoussis G, Denny JC, Dominiczak A, Dubé MP, Ebeling T, Eiriksdottir G, Esko T, Farmaki AE, Feitosa MF, Ferrario M, Ferrieres J, Ford I, Fornage M, Franks PW, Frayling TM, Frikke-Schmidt R, Fritsche LG, Frossard P, Fuster V, Ganesh SK, Gao W, Garcia ME, Gieger C, Giulianini F, Goodarzi MO, Grallert H, Grarup N, Groop L, Grove ML, Gudnason V, Hansen T, Harris TB, Hayward C, Hirschhorn JN, Holmen OL, Huffman J, Huo Y, Hveem K, Jabeen S, Jackson AU, Jakobsdottir J, Jarvelin MR, Jensen GB, Jørgensen ME, Jukema JW, Justesen JM, Kamstrup PR, Kanoni S, Karpe F, Kee F, Khera AV, Klarin D, Koistinen HA, Kooner JS, Kooperberg C, Kuulasmaa K, Kuusisto J, Laakso M, Lakka T, Langenberg C, Langsted A, Launer LJ, Lauritzen T, Liewald DCM, Lin L… See abstract for full author list ➔ Liu DJ, et al. Among authors: sivapalaratnam s. Nat Genet. 2017 Dec;49(12):1758-1766. doi: 10.1038/ng.3977. Epub 2017 Oct 30. Nat Genet. 2017. PMID: 29083408 Free PMC article.
Genome-wide association studies in atherosclerosis.
Sivapalaratnam S, Motazacker MM, Maiwald S, Hovingh GK, Kastelein JJ, Levi M, Trip MD, Dallinga-Thie GM. Sivapalaratnam S, et al. Curr Atheroscler Rep. 2011 Jun;13(3):225-32. doi: 10.1007/s11883-011-0173-4. Curr Atheroscler Rep. 2011. PMID: 21369780 Free PMC article. Review.
Platelets in patients with premature coronary artery disease exhibit upregulation of miRNA340* and miRNA624*.
Sondermeijer BM, Bakker A, Halliani A, de Ronde MW, Marquart AA, Tijsen AJ, Mulders TA, Kok MG, Battjes S, Maiwald S, Sivapalaratnam S, Trip MD, Moerland PD, Meijers JC, Creemers EE, Pinto-Sietsma SJ. Sondermeijer BM, et al. Among authors: sivapalaratnam s. PLoS One. 2011;6(10):e25946. doi: 10.1371/journal.pone.0025946. Epub 2011 Oct 13. PLoS One. 2011. PMID: 22022480 Free PMC article.
Asymptomatic individuals with a positive family history for premature coronary artery disease and elevated coronary calcium scores benefit from statin treatment: a post hoc analysis from the St. Francis Heart Study.
Mulders TA, Sivapalaratnam S, Stroes ES, Kastelein JJ, Guerci AD, Pinto-Sietsma SJ. Mulders TA, et al. Among authors: sivapalaratnam s. JACC Cardiovasc Imaging. 2012 Mar;5(3):252-60. doi: 10.1016/j.jcmg.2011.11.014. JACC Cardiovasc Imaging. 2012. PMID: 22421169 Free article. Clinical Trial.
82 results