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The impact of partial and complete loss-of-function mutations in endothelial lipase on high-density lipoprotein levels and functionality in humans.
Singaraja RR, Sivapalaratnam S, Hovingh K, Dubé MP, Castro-Perez J, Collins HL, Adelman SJ, Riwanto M, Manz J, Hubbard B, Tietjen I, Wong K, Mitnaul LJ, van Heek M, Lin L, Roddy TA, McEwen J, Dallinge-Thie G, van Vark-van der Zee L, Verwoert G, Winther M, van Duijn C, Hofman A, Trip MD, Marais AD, Asztalos B, Landmesser U, Sijbrands E, Kastelein JJ, Hayden MR. Singaraja RR, et al. Among authors: van vark van der zee l, van duijn c, van heek m. Circ Cardiovasc Genet. 2013 Feb;6(1):54-62. doi: 10.1161/CIRCGENETICS.111.962613. Epub 2012 Dec 14. Circ Cardiovasc Genet. 2013. PMID: 23243195 Free article.
Identification of four novel genes contributing to familial elevated plasma HDL cholesterol in humans.
Singaraja RR, Tietjen I, Hovingh GK, Franchini PL, Radomski C, Wong K, vanHeek M, Stylianou IM, Lin L, Wang L, Mitnaul L, Hubbard B, Winther M, Mattice M, Legendre A, Sherrington R, Kastelein JJ, Akinsanya K, Plump A, Hayden MR. Singaraja RR, et al. J Lipid Res. 2014 Aug;55(8):1693-701. doi: 10.1194/jlr.M048710. Epub 2014 Jun 2. J Lipid Res. 2014. PMID: 24891332 Free PMC article.
Discovery of novel quinoline carboxylic acid series as DGAT1 inhibitors.
Zhou G, Ting PC, Wishart G, Zorn N, Aslanian RG, Lin M, Smith M, Walker SS, Cook J, Van Heek M, Lachowicz J. Zhou G, et al. Among authors: van heek m. Bioorg Med Chem Lett. 2014 Apr 1;24(7):1790-4. doi: 10.1016/j.bmcl.2014.02.028. Epub 2014 Feb 19. Bioorg Med Chem Lett. 2014. PMID: 24618302
Discovery of phenyl acetamides as potent and selective GPR119 agonists.
Zhu C, Wang L, Zhu Y, Guo ZZ, Liu P, Hu Z, Szewczyk JW, Kang L, Chicchi G, Ehrhardt A, Woods A, Seo T, Woods M, van Heek M, Dingley KH, Pang J, Salituro GM, Powell J, Terebetski JL, Hornak V, Campeau LC, Orr RK, Ujjainwalla F, Miller M, Stamford A, Wood HB, Kowalski T, Nargund RP, Edmondson SD. Zhu C, et al. Among authors: van heek m. Bioorg Med Chem Lett. 2017 Mar 1;27(5):1124-1128. doi: 10.1016/j.bmcl.2017.01.091. Epub 2017 Feb 1. Bioorg Med Chem Lett. 2017. PMID: 28185720
Lead optimization of a pyridine-carboxamide series as DGAT-1 inhibitors.
Ting PC, Lee JF, Zorn N, Kim HM, Aslanian RG, Lin M, Smith M, Walker SS, Cook J, Van Heek M, Lachowicz J. Ting PC, et al. Among authors: van heek m. Bioorg Med Chem Lett. 2013 Feb 15;23(4):985-8. doi: 10.1016/j.bmcl.2012.12.040. Epub 2012 Dec 21. Bioorg Med Chem Lett. 2013. PMID: 23317570
Discovery of liver-targeted inhibitors of stearoyl-CoA desaturase (SCD1).
Deng Y, Yang Z, Shipps GW Jr, Lo SM, West R, Hwa J, Zheng S, Farley C, Lachowicz J, van Heek M, Bass AS, Sinha DP, Mahon CR, Cartwright ME. Deng Y, et al. Among authors: van heek m. Bioorg Med Chem Lett. 2013 Feb 1;23(3):791-6. doi: 10.1016/j.bmcl.2012.11.075. Epub 2012 Dec 5. Bioorg Med Chem Lett. 2013. PMID: 23265904
Tetrahydroisoquinolines as MCH-R1 antagonists.
Sasikumar TK, Qiang L, Wu WL, Burnett DA, Greenlee WJ, O'Neill K, Hawes BE, van Heek M, Graziano M. Sasikumar TK, et al. Among authors: van heek m. Bioorg Med Chem Lett. 2006 Sep 15;16(18):4917-21. doi: 10.1016/j.bmcl.2006.06.055. Epub 2006 Jul 7. Bioorg Med Chem Lett. 2006. PMID: 16824753
44 results