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C9orf72 repeat expansions cause neurodegeneration in Drosophila through arginine-rich proteins.
Mizielinska S, Grönke S, Niccoli T, Ridler CE, Clayton EL, Devoy A, Moens T, Norona FE, Woollacott IOC, Pietrzyk J, Cleverley K, Nicoll AJ, Pickering-Brown S, Dols J, Cabecinha M, Hendrich O, Fratta P, Fisher EMC, Partridge L, Isaacs AM. Mizielinska S, et al. Among authors: nicoll aj. Science. 2014 Sep 5;345(6201):1192-1194. doi: 10.1126/science.1256800. Epub 2014 Aug 7. Science. 2014. PMID: 25103406 Free PMC article.
G-quadruplex-binding small molecules ameliorate C9orf72 FTD/ALS pathology in vitro and in vivo.
Simone R, Balendra R, Moens TG, Preza E, Wilson KM, Heslegrave A, Woodling NS, Niccoli T, Gilbert-Jaramillo J, Abdelkarim S, Clayton EL, Clarke M, Konrad MT, Nicoll AJ, Mitchell JS, Calvo A, Chio A, Houlden H, Polke JM, Ismail MA, Stephens CE, Vo T, Farahat AA, Wilson WD, Boykin DW, Zetterberg H, Partridge L, Wray S, Parkinson G, Neidle S, Patani R, Fratta P, Isaacs AM. Simone R, et al. Among authors: nicoll aj. EMBO Mol Med. 2018 Jan;10(1):22-31. doi: 10.15252/emmm.201707850. EMBO Mol Med. 2018. PMID: 29113975 Free PMC article.
Pharmacological chaperone for the structured domain of human prion protein.
Nicoll AJ, Trevitt CR, Tattum MH, Risse E, Quarterman E, Ibarra AA, Wright C, Jackson GS, Sessions RB, Farrow M, Waltho JP, Clarke AR, Collinge J. Nicoll AJ, et al. Proc Natl Acad Sci U S A. 2010 Oct 12;107(41):17610-5. doi: 10.1073/pnas.1009062107. Epub 2010 Sep 27. Proc Natl Acad Sci U S A. 2010. PMID: 20876144 Free PMC article.
N-terminal domain of prion protein directs its oligomeric association.
Trevitt CR, Hosszu LL, Batchelor M, Panico S, Terry C, Nicoll AJ, Risse E, Taylor WA, Sandberg MK, Al-Doujaily H, Linehan JM, Saibil HR, Scott DJ, Collinge J, Waltho JP, Clarke AR. Trevitt CR, et al. Among authors: nicoll aj. J Biol Chem. 2014 Sep 12;289(37):25497-508. doi: 10.1074/jbc.M114.566588. Epub 2014 Jul 29. J Biol Chem. 2014. PMID: 25074940 Free PMC article.
Soluble Aβ aggregates can inhibit prion propagation.
Sarell CJ, Quarterman E, Yip DC, Terry C, Nicoll AJ, Wadsworth JDF, Farrow MA, Walsh DM, Collinge J. Sarell CJ, et al. Among authors: nicoll aj. Open Biol. 2017 Nov;7(11):170158. doi: 10.1098/rsob.170158. Open Biol. 2017. PMID: 29142106 Free PMC article.
84 results