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Imbalance of Hsp70 family variants fosters tau accumulation.
Jinwal UK, Akoury E, Abisambra JF, O'Leary JC 3rd, Thompson AD, Blair LJ, Jin Y, Bacon J, Nordhues BA, Cockman M, Zhang J, Li P, Zhang B, Borysov S, Uversky VN, Biernat J, Mandelkow E, Gestwicki JE, Zweckstetter M, Dickey CA. Jinwal UK, et al. Among authors: cockman m. FASEB J. 2013 Apr;27(4):1450-9. doi: 10.1096/fj.12-220889. Epub 2012 Dec 27. FASEB J. 2013. PMID: 23271055 Free PMC article.
DnaJA1 antagonizes constitutive Hsp70-mediated stabilization of tau.
Abisambra JF, Jinwal UK, Suntharalingam A, Arulselvam K, Brady S, Cockman M, Jin Y, Zhang B, Dickey CA. Abisambra JF, et al. Among authors: cockman m. J Mol Biol. 2012 Aug 24;421(4-5):653-61. doi: 10.1016/j.jmb.2012.02.003. Epub 2012 Feb 15. J Mol Biol. 2012. PMID: 22343013 Free PMC article.
Allosteric heat shock protein 70 inhibitors rapidly rescue synaptic plasticity deficits by reducing aberrant tau.
Abisambra J, Jinwal UK, Miyata Y, Rogers J, Blair L, Li X, Seguin SP, Wang L, Jin Y, Bacon J, Brady S, Cockman M, Guidi C, Zhang J, Koren J, Young ZT, Atkins CA, Zhang B, Lawson LY, Weeber EJ, Brodsky JL, Gestwicki JE, Dickey CA. Abisambra J, et al. Among authors: cockman m. Biol Psychiatry. 2013 Sep 1;74(5):367-74. doi: 10.1016/j.biopsych.2013.02.027. Epub 2013 Apr 19. Biol Psychiatry. 2013. PMID: 23607970 Free PMC article.
Glucose-regulated protein 94 triage of mutant myocilin through endoplasmic reticulum-associated degradation subverts a more efficient autophagic clearance mechanism.
Suntharalingam A, Abisambra JF, O'Leary JC 3rd, Koren J 3rd, Zhang B, Joe MK, Blair LJ, Hill SE, Jinwal UK, Cockman M, Duerfeldt AS, Tomarev S, Blagg BS, Lieberman RL, Dickey CA. Suntharalingam A, et al. Among authors: cockman m. J Biol Chem. 2012 Nov 23;287(48):40661-9. doi: 10.1074/jbc.M112.384800. Epub 2012 Oct 3. J Biol Chem. 2012. PMID: 23035116 Free PMC article.
Tau accumulation activates the unfolded protein response by impairing endoplasmic reticulum-associated degradation.
Abisambra JF, Jinwal UK, Blair LJ, O'Leary JC 3rd, Li Q, Brady S, Wang L, Guidi CE, Zhang B, Nordhues BA, Cockman M, Suntharalingham A, Li P, Jin Y, Atkins CA, Dickey CA. Abisambra JF, et al. Among authors: cockman m. J Neurosci. 2013 May 29;33(22):9498-507. doi: 10.1523/JNEUROSCI.5397-12.2013. J Neurosci. 2013. PMID: 23719816 Free PMC article.
Oxygenase-catalyzed ribosome hydroxylation occurs in prokaryotes and humans.
Ge W, Wolf A, Feng T, Ho CH, Sekirnik R, Zayer A, Granatino N, Cockman ME, Loenarz C, Loik ND, Hardy AP, Claridge TDW, Hamed RB, Chowdhury R, Gong L, Robinson CV, Trudgian DC, Jiang M, Mackeen MM, Mccullagh JS, Gordiyenko Y, Thalhammer A, Yamamoto A, Yang M, Liu-Yi P, Zhang Z, Schmidt-Zachmann M, Kessler BM, Ratcliffe PJ, Preston GM, Coleman ML, Schofield CJ. Ge W, et al. Among authors: cockman me. Nat Chem Biol. 2012 Dec;8(12):960-962. doi: 10.1038/nchembio.1093. Epub 2012 Oct 28. Nat Chem Biol. 2012. PMID: 23103944 Free PMC article.
51 results