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Fibroblast growth factor 21 mediates specific glucagon actions.
Habegger KM, Stemmer K, Cheng C, Müller TD, Heppner KM, Ottaway N, Holland J, Hembree JL, Smiley D, Gelfanov V, Krishna R, Arafat AM, Konkar A, Belli S, Kapps M, Woods SC, Hofmann SM, D'Alessio D, Pfluger PT, Perez-Tilve D, Seeley RJ, Konishi M, Itoh N, Kharitonenkov A, Spranger J, DiMarchi RD, Tschöp MH. Habegger KM, et al. Among authors: cheng c. Diabetes. 2013 May;62(5):1453-63. doi: 10.2337/db12-1116. Epub 2013 Jan 10. Diabetes. 2013. PMID: 23305646 Free PMC article. Clinical Trial.
FGF21 requires βklotho to act in vivo.
Adams AC, Cheng CC, Coskun T, Kharitonenkov A. Adams AC, et al. Among authors: cheng cc. PLoS One. 2012;7(11):e49977. doi: 10.1371/journal.pone.0049977. Epub 2012 Nov 27. PLoS One. 2012. PMID: 23209629 Free PMC article.
An FGF21-adiponectin-ceramide axis controls energy expenditure and insulin action in mice.
Holland WL, Adams AC, Brozinick JT, Bui HH, Miyauchi Y, Kusminski CM, Bauer SM, Wade M, Singhal E, Cheng CC, Volk K, Kuo MS, Gordillo R, Kharitonenkov A, Scherer PE. Holland WL, et al. Among authors: cheng cc. Cell Metab. 2013 May 7;17(5):790-7. doi: 10.1016/j.cmet.2013.03.019. Cell Metab. 2013. PMID: 23663742 Free PMC article.
Rational design of a fibroblast growth factor 21-based clinical candidate, LY2405319.
Kharitonenkov A, Beals JM, Micanovic R, Strifler BA, Rathnachalam R, Wroblewski VJ, Li S, Koester A, Ford AM, Coskun T, Dunbar JD, Cheng CC, Frye CC, Bumol TF, Moller DE. Kharitonenkov A, et al. Among authors: cheng cc. PLoS One. 2013;8(3):e58575. doi: 10.1371/journal.pone.0058575. Epub 2013 Mar 11. PLoS One. 2013. PMID: 23536797 Free PMC article.
Interplay between FGF21 and insulin action in the liver regulates metabolism.
Emanuelli B, Vienberg SG, Smyth G, Cheng C, Stanford KI, Arumugam M, Michael MD, Adams AC, Kharitonenkov A, Kahn CR. Emanuelli B, et al. Among authors: cheng c. J Clin Invest. 2014 Feb;124(2):515-27. doi: 10.1172/JCI67353. Epub 2014 Jan 9. J Clin Invest. 2014. PMID: 24401271 Free PMC article.
Discrete Aspects of FGF21 In Vivo Pharmacology Do Not Require UCP1.
Samms RJ, Smith DP, Cheng CC, Antonellis PP, Perfield JW 2nd, Kharitonenkov A, Gimeno RE, Adams AC. Samms RJ, et al. Among authors: cheng cc. Cell Rep. 2015 May 19;11(7):991-9. doi: 10.1016/j.celrep.2015.04.046. Epub 2015 May 5. Cell Rep. 2015. PMID: 25956583 Free article.
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