Wei J - Search Results

1

A Pan-BCL2 inhibitor renders bone-marrow-resident human leukemia stem cells sensitive to tyrosine kinase inhibition.

Goff DJ, Court Recart A, Sadarangani A, Chun HJ, Barrett CL, Krajewska M, Leu H, Low-Marchelli J, Ma W, Shih AY, Wei J, Zhai D, Geron I, Pu M, Bao L, Chuang R, Balaian L, Gotlib J, Minden M, Martinelli G, Rusert J, Dao KH, Shazand K, Wentworth P, Smith KM, Jamieson CA, Morris SR, Messer K, Goldstein LS, Hudson TJ, Marra M, Frazer KA, Pellecchia M, Reed JC, Jamieson CH. Goff DJ, et al. Among authors: wei j. Cell Stem Cell. 2013 Mar 7;12(3):316-28. doi: 10.1016/j.stem.2012.12.011. Epub 2013 Jan 17. Cell Stem Cell. 2013. PMID: 23333150 Free PMC article.

2

A survey of the anti-apoptotic Bcl-2 subfamily expression in cancer types provides a platform to predict the efficacy of Bcl-2 antagonists in cancer therapy.

Placzek WJ, Wei J, Kitada S, Zhai D, Reed JC, Pellecchia M. Placzek WJ, et al. Among authors: wei j. Cell Death Dis. 2010 May 6;1(5):e40. doi: 10.1038/cddis.2010.18. Cell Death Dis. 2010. PMID: 21364647 Free PMC article.

3

Apogossypol derivatives as pan-active inhibitors of antiapoptotic B-cell lymphoma/leukemia-2 (Bcl-2) family proteins.

Wei J, Kitada S, Rega MF, Stebbins JL, Zhai D, Cellitti J, Yuan H, Emdadi A, Dahl R, Zhang Z, Yang L, Reed JC, Pellecchia M. Wei J, et al. J Med Chem. 2009 Jul 23;52(14):4511-23. doi: 10.1021/jm900472s. J Med Chem. 2009. PMID: 19555126 Free PMC article.

4

BI-97C1, an optically pure Apogossypol derivative as pan-active inhibitor of antiapoptotic B-cell lymphoma/leukemia-2 (Bcl-2) family proteins.

Wei J, Stebbins JL, Kitada S, Dash R, Placzek W, Rega MF, Wu B, Cellitti J, Zhai D, Yang L, Dahl R, Fisher PB, Reed JC, Pellecchia M. Wei J, et al. J Med Chem. 2010 May 27;53(10):4166-76. doi: 10.1021/jm1001265. J Med Chem. 2010. PMID: 20443627 Free PMC article.

5

Inhibition of Mcl-1 with the pan-Bcl-2 family inhibitor (-)BI97D6 overcomes ABT-737 resistance in acute myeloid leukemia.

Pan R, Ruvolo VR, Wei J, Konopleva M, Reed JC, Pellecchia M, Andreeff M, Ruvolo PP. Pan R, et al. Among authors: wei j. Blood. 2015 Jul 16;126(3):363-72. doi: 10.1182/blood-2014-10-604975. Epub 2015 Jun 4. Blood. 2015. PMID: 26045609 Free PMC article.

6

Synthesis and biological evaluation of Apogossypolone derivatives as pan-active inhibitors of antiapoptotic B-cell lymphoma/leukemia-2 (Bcl-2) family proteins.

Wei J, Kitada S, Stebbins JL, Placzek W, Zhai D, Wu B, Rega MF, Zhang Z, Cellitti J, Yang L, Dahl R, Reed JC, Pellecchia M. Wei J, et al. J Med Chem. 2010 Nov 25;53(22):8000-11. doi: 10.1021/jm100746q. Epub 2010 Oct 29. J Med Chem. 2010. PMID: 21033669 Free PMC article.

7

Synthesis and evaluation of Apogossypol atropisomers as potential Bcl-xL antagonists.

Wei J, Rega MF, Kitada S, Yuan H, Zhai D, Risbood P, Seltzman HH, Twine CE, Reed JC, Pellecchia M. Wei J, et al. Cancer Lett. 2009 Jan 8;273(1):107-13. doi: 10.1016/j.canlet.2008.07.031. Epub 2008 Sep 7. Cancer Lett. 2009. PMID: 18782651 Free PMC article.

8

Apogossypol derivatives as antagonists of antiapoptotic Bcl-2 family proteins.

Wei J, Kitada S, Rega MF, Emdadi A, Yuan H, Cellitti J, Stebbins JL, Zhai D, Sun J, Yang L, Dahl R, Zhang Z, Wu B, Wang S, Reed TA, Wang HG, Lawrence N, Sebti S, Reed JC, Pellecchia M. Wei J, et al. Mol Cancer Ther. 2009 Apr;8(4):904-13. doi: 10.1158/1535-7163.MCT-08-1050. Mol Cancer Ther. 2009. PMID: 19372563 Free PMC article.

9

SAR by interligand nuclear overhauser effects (ILOEs) based discovery of acylsulfonamide compounds active against Bcl-x(L) and Mcl-1.

Rega MF, Wu B, Wei J, Zhang Z, Cellitti JF, Pellecchia M. Rega MF, et al. Among authors: wei j. J Med Chem. 2011 Sep 8;54(17):6000-13. doi: 10.1021/jm200826s. Epub 2011 Aug 4. J Med Chem. 2011. PMID: 21797225 Free PMC article.

10

Identification of a novel Mcl-1 protein binding motif.

Placzek WJ, Sturlese M, Wu B, Cellitti JF, Wei J, Pellecchia M. Placzek WJ, et al. Among authors: wei j. J Biol Chem. 2011 Nov 18;286(46):39829-35. doi: 10.1074/jbc.M111.305326. Epub 2011 Sep 27. J Biol Chem. 2011. PMID: 21953453 Free PMC article.

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