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Link between GIP and osteopontin in adipose tissue and insulin resistance.
Ahlqvist E, Osmark P, Kuulasmaa T, Pilgaard K, Omar B, Brøns C, Kotova O, Zetterqvist AV, Stancáková A, Jonsson A, Hansson O, Kuusisto J, Kieffer TJ, Tuomi T, Isomaa B, Madsbad S, Gomez MF, Poulsen P, Laakso M, Degerman E, Pihlajamäki J, Wierup N, Vaag A, Groop L, Lyssenko V. Ahlqvist E, et al. Among authors: kieffer tj. Diabetes. 2013 Jun;62(6):2088-94. doi: 10.2337/db12-0976. Epub 2013 Jan 24. Diabetes. 2013. PMID: 23349498 Free PMC article.
Pleiotropic effects of GIP on islet function involve osteopontin.
Lyssenko V, Eliasson L, Kotova O, Pilgaard K, Wierup N, Salehi A, Wendt A, Jonsson A, De Marinis YZ, Berglund LM, Taneera J, Balhuizen A, Hansson O, Osmark P, Dunér P, Brøns C, Stancáková A, Kuusisto J, Bugliani M, Saxena R, Ahlqvist E, Kieffer TJ, Tuomi T, Isomaa B, Melander O, Sonestedt E, Orho-Melander M, Nilsson P, Bonetti S, Bonadonna R, Miccoli R, Delprato S, Marchetti P, Madsbad S, Poulsen P, Vaag A, Laakso M, Gomez MF, Groop L. Lyssenko V, et al. Among authors: kieffer tj. Diabetes. 2011 Sep;60(9):2424-33. doi: 10.2337/db10-1532. Epub 2011 Aug 1. Diabetes. 2011. PMID: 21810601 Free PMC article.
Glucose-Dependent Insulinotropic Polypeptide Stimulates Osteopontin Expression in the Vasculature via Endothelin-1 and CREB.
Berglund LM, Lyssenko V, Ladenvall C, Kotova O, Edsfeldt A, Pilgaard K, Alkayyali S, Brøns C, Forsblom C, Jonsson A, Zetterqvist AV, Nitulescu M, McDavitt CR, Dunér P, Stancáková A, Kuusisto J, Ahlqvist E, Lajer M, Tarnow L, Madsbad S, Rossing P, Kieffer TJ, Melander O, Orho-Melander M, Nilsson P, Groop PH, Vaag A, Lindblad B, Gottsäter A, Laakso M, Goncalves I, Groop L, Gomez MF. Berglund LM, et al. Among authors: kieffer tj. Diabetes. 2016 Jan;65(1):239-54. doi: 10.2337/db15-0122. Epub 2015 Sep 22. Diabetes. 2016. PMID: 26395740
Glucose-dependent insulinotropic polypeptide deficiency reduced fat accumulation and insulin resistance, but deteriorated bone loss in ovariectomized mice.
Shimazu-Kuwahara S, Kanemaru Y, Harada N, Ikeguchi E, Ueda Y, Yamane S, Murata Y, Yasoda A, Kieffer TJ, Inagaki N. Shimazu-Kuwahara S, et al. Among authors: kieffer tj. J Diabetes Investig. 2019 Jul;10(4):909-914. doi: 10.1111/jdi.12978. Epub 2018 Dec 27. J Diabetes Investig. 2019. PMID: 30451382 Free PMC article.
Functional GIP receptors are present on adipocytes.
Yip RG, Boylan MO, Kieffer TJ, Wolfe MM. Yip RG, et al. Among authors: kieffer tj. Endocrinology. 1998 Sep;139(9):4004-7. doi: 10.1210/endo.139.9.6288. Endocrinology. 1998. PMID: 9724057
206 results