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A small molecule inhibitor of the BLM helicase modulates chromosome stability in human cells.
Nguyen GH, Dexheimer TS, Rosenthal AS, Chu WK, Singh DK, Mosedale G, Bachrati CZ, Schultz L, Sakurai M, Savitsky P, Abu M, McHugh PJ, Bohr VA, Harris CC, Jadhav A, Gileadi O, Maloney DJ, Simeonov A, Hickson ID. Nguyen GH, et al. Among authors: harris cc. Chem Biol. 2013 Jan 24;20(1):55-62. doi: 10.1016/j.chembiol.2012.10.016. Chem Biol. 2013. PMID: 23352139 Free PMC article.
Regulation of gene expression by the BLM helicase correlates with the presence of G-quadruplex DNA motifs.
Nguyen GH, Tang W, Robles AI, Beyer RP, Gray LT, Welsh JA, Schetter AJ, Kumamoto K, Wang XW, Hickson ID, Maizels N, Monnat RJ Jr, Harris CC. Nguyen GH, et al. Among authors: harris cc. Proc Natl Acad Sci U S A. 2014 Jul 8;111(27):9905-10. doi: 10.1073/pnas.1404807111. Epub 2014 Jun 23. Proc Natl Acad Sci U S A. 2014. PMID: 24958861 Free PMC article.
The processing of Holliday junctions by BLM and WRN helicases is regulated by p53.
Yang Q, Zhang R, Wang XW, Spillare EA, Linke SP, Subramanian D, Griffith JD, Li JL, Hickson ID, Shen JC, Loeb LA, Mazur SJ, Appella E, Brosh RM Jr, Karmakar P, Bohr VA, Harris CC. Yang Q, et al. Among authors: harris cc. J Biol Chem. 2002 Aug 30;277(35):31980-7. doi: 10.1074/jbc.M204111200. Epub 2002 Jun 21. J Biol Chem. 2002. PMID: 12080066 Free article.
p53 Modulates the exonuclease activity of Werner syndrome protein.
Brosh RM Jr, Karmakar P, Sommers JA, Yang Q, Wang XW, Spillare EA, Harris CC, Bohr VA. Brosh RM Jr, et al. Among authors: harris cc. J Biol Chem. 2001 Sep 14;276(37):35093-102. doi: 10.1074/jbc.M103332200. Epub 2001 Jun 26. J Biol Chem. 2001. PMID: 11427532 Free article.
The mismatch DNA repair heterodimer, hMSH2/6, regulates BLM helicase.
Yang Q, Zhang R, Wang XW, Linke SP, Sengupta S, Hickson ID, Pedrazzi G, Perrera C, Stagljar I, Littman SJ, Modrich P, Harris CC. Yang Q, et al. Among authors: harris cc. Oncogene. 2004 May 6;23(21):3749-56. doi: 10.1038/sj.onc.1207462. Oncogene. 2004. PMID: 15064730
Redundancy of DNA helicases in p53-mediated apoptosis.
Spillare EA, Wang XW, von Kobbe C, Bohr VA, Hickson ID, Harris CC. Spillare EA, et al. Among authors: harris cc. Oncogene. 2006 Mar 30;25(14):2119-23. doi: 10.1038/sj.onc.1209242. Oncogene. 2006. PMID: 16288211 Free PMC article.
806 results