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RhoA protects the mouse heart against ischemia/reperfusion injury.
Xiang SY, Vanhoutte D, Del Re DP, Purcell NH, Ling H, Banerjee I, Bossuyt J, Lang RA, Zheng Y, Matkovich SJ, Miyamoto S, Molkentin JD, Dorn GW 2nd, Brown JH. Xiang SY, et al. Among authors: purcell nh. J Clin Invest. 2011 Aug;121(8):3269-76. doi: 10.1172/JCI44371. Epub 2011 Jul 11. J Clin Invest. 2011. PMID: 21747165 Free PMC article.
PHLPP-1 negatively regulates Akt activity and survival in the heart.
Miyamoto S, Purcell NH, Smith JM, Gao T, Whittaker R, Huang K, Castillo R, Glembotski CC, Sussman MA, Newton AC, Brown JH. Miyamoto S, et al. Among authors: purcell nh. Circ Res. 2010 Aug 20;107(4):476-84. doi: 10.1161/CIRCRESAHA.109.215020. Epub 2010 Jun 24. Circ Res. 2010. PMID: 20576936 Free PMC article.
APJ acts as a dual receptor in cardiac hypertrophy.
Scimia MC, Hurtado C, Ray S, Metzler S, Wei K, Wang J, Woods CE, Purcell NH, Catalucci D, Akasaka T, Bueno OF, Vlasuk GP, Kaliman P, Bodmer R, Smith LH, Ashley E, Mercola M, Brown JH, Ruiz-Lozano P. Scimia MC, et al. Among authors: purcell nh. Nature. 2012 Aug 16;488(7411):394-8. doi: 10.1038/nature11263. Nature. 2012. PMID: 22810587 Free PMC article.
PHLPP1 gene deletion protects the brain from ischemic injury.
Chen B, Van Winkle JA, Lyden PD, Brown JH, Purcell NH. Chen B, et al. Among authors: purcell nh. J Cereb Blood Flow Metab. 2013 Feb;33(2):196-204. doi: 10.1038/jcbfm.2012.150. Epub 2012 Oct 17. J Cereb Blood Flow Metab. 2013. PMID: 23072745 Free PMC article.
28 results