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Genetic and pharmacological modifications of thrombin formation in apolipoprotein e-deficient mice determine atherosclerosis severity and atherothrombosis onset in a neutrophil-dependent manner.
Borissoff JI, Otten JJ, Heeneman S, Leenders P, van Oerle R, Soehnlein O, Loubele ST, Hamulyák K, Hackeng TM, Daemen MJ, Degen JL, Weiler H, Esmon CT, van Ryn J, Biessen EA, Spronk HM, ten Cate H. Borissoff JI, et al. Among authors: esmon ct. PLoS One. 2013;8(2):e55784. doi: 10.1371/journal.pone.0055784. Epub 2013 Feb 7. PLoS One. 2013. PMID: 23409043 Free PMC article.
Thrombomodulin mutant mice with a strongly reduced capacity to generate activated protein C have an unaltered pulmonary immune response to respiratory pathogens and lipopolysaccharide.
Rijneveld AW, Weijer S, Florquin S, Esmon CT, Meijers JC, Speelman P, Reitsma PH, Ten Cate H, van der Poll T. Rijneveld AW, et al. Among authors: esmon ct. Blood. 2004 Mar 1;103(5):1702-9. doi: 10.1182/blood-2002-05-1380. Epub 2003 Oct 30. Blood. 2004. PMID: 14592828 Free article.
The development of inflammatory joint disease is attenuated in mice expressing the anticoagulant prothrombin mutant W215A/E217A.
Flick MJ, Chauhan AK, Frederick M, Talmage KE, Kombrinck KW, Miller W, Mullins ES, Palumbo JS, Zheng X, Esmon NL, Esmon CT, Thornton S, Becker A, Pelc LA, Di Cera E, Wagner DD, Degen JL. Flick MJ, et al. Among authors: esmon ct, esmon nl. Blood. 2011 Jun 9;117(23):6326-37. doi: 10.1182/blood-2010-08-304915. Epub 2011 Mar 24. Blood. 2011. PMID: 21436072 Free PMC article.
397 results