van Ryn J - Search Results

1

Genetic and pharmacological modifications of thrombin formation in apolipoprotein e-deficient mice determine atherosclerosis severity and atherothrombosis onset in a neutrophil-dependent manner.

Borissoff JI, Otten JJ, Heeneman S, Leenders P, van Oerle R, Soehnlein O, Loubele ST, Hamulyák K, Hackeng TM, Daemen MJ, Degen JL, Weiler H, Esmon CT, van Ryn J, Biessen EA, Spronk HM, ten Cate H. Borissoff JI, et al. Among authors: van ryn j, van oerle r. PLoS One. 2013;8(2):e55784. doi: 10.1371/journal.pone.0055784. Epub 2013 Feb 7. PLoS One. 2013. PMID: 23409043 Free PMC article.

2

Measurement of dabigatran in standardly used clinical assays, whole blood viscoelastic coagulation, and thrombin generation assays.

van Ryn J, Grottke O, Spronk H. van Ryn J, et al. Clin Lab Med. 2014 Sep;34(3):479-501. doi: 10.1016/j.cll.2014.06.008. Epub 2014 Jul 22. Clin Lab Med. 2014. PMID: 25168938 Review.

3

Prothrombin Complex Concentrate Is Effective in Treating the Anticoagulant Effects of Dabigatran in a Porcine Polytrauma Model.

Honickel M, Braunschweig T, van Ryn J, Ten Cate H, Spronk HM, Rossaint R, Grottke O. Honickel M, et al. Among authors: van ryn j. Anesthesiology. 2015 Dec;123(6):1350-61. doi: 10.1097/ALN.0000000000000863. Anesthesiology. 2015. PMID: 26414500 Free article.

4

Volume replacement strategies do not impair the binding of dabigatran to idarucizumab: Porcine model of hemodilution.

Grottke O, van Ryn J, Zentai C, Gan G, Honickel M, Rossaint R, Ten Cate H, Spronk HMH. Grottke O, et al. Among authors: van ryn j. PLoS One. 2019 Jan 7;14(1):e0209350. doi: 10.1371/journal.pone.0209350. eCollection 2019. PLoS One. 2019. PMID: 30615630 Free PMC article.

5

Off-target effects of oral anticoagulants - vascular effects of vitamin K antagonist and non-vitamin K antagonist oral anticoagulant dabigatran etexilate.

van Gorp RH, Dijkgraaf I, Bröker V, Bauwens M, Leenders P, Jennen D, Dweck MR, Bucerius J, Briedé JJ, van Ryn J, Brandenburg V, Mottaghy F, Spronk HMH, Reutelingsperger CP, Schurgers LJ. van Gorp RH, et al. Among authors: van ryn j. J Thromb Haemost. 2021 May;19(5):1348-1363. doi: 10.1111/jth.15289. Epub 2021 Mar 28. J Thromb Haemost. 2021. PMID: 33687782 Free PMC article.

6

Prothrombin complex concentrates and a specific antidote to dabigatran are effective ex-vivo in reversing the effects of dabigatran in an anticoagulation/liver trauma experimental model.

Grottke O, van Ryn J, Spronk HM, Rossaint R. Grottke O, et al. Among authors: van ryn j. Crit Care. 2014 Feb 5;18(1):R27. doi: 10.1186/cc13717. Crit Care. 2014. PMID: 24499559 Free PMC article.

7

Porcine blood and surrogate markers do not prove benefit of aDabi-Fab. Authors' response.

Grottke O, van Ryn J, Spronk HM, Rossaint R. Grottke O, et al. Among authors: van ryn j. Crit Care. 2014 Jun 17;18(3):435. Crit Care. 2014. PMID: 25473658 No abstract available.

8

Therapy with activated prothrombin complex concentrate is effective in reducing dabigatran-associated blood loss in a porcine polytrauma model.

Honickel M, Maron B, van Ryn J, Braunschweig T, ten Cate H, Spronk HM, Rossaint R, Grottke O. Honickel M, et al. Among authors: van ryn j. Thromb Haemost. 2016 Jan;115(2):271-84. doi: 10.1160/TH15-03-0266. Epub 2015 Sep 3. Thromb Haemost. 2016. PMID: 26333775

9

Thrombin promotes diet-induced obesity through fibrin-driven inflammation.

Kopec AK, Abrahams SR, Thornton S, Palumbo JS, Mullins ES, Divanovic S, Weiler H, Owens AP 3rd, Mackman N, Goss A, van Ryn J, Luyendyk JP, Flick MJ. Kopec AK, et al. Among authors: van ryn j. J Clin Invest. 2017 Aug 1;127(8):3152-3166. doi: 10.1172/JCI92744. Epub 2017 Jul 24. J Clin Invest. 2017. PMID: 28737512 Free PMC article.

10

Idarucizumab, a Specific Dabigatran Reversal Agent, Reduces Blood Loss in a Porcine Model of Trauma With Dabigatran Anticoagulation.

Grottke O, Honickel M, van Ryn J, ten Cate H, Rossaint R, Spronk HM. Grottke O, et al. Among authors: van ryn j. J Am Coll Cardiol. 2015 Sep 29;66(13):1518-9. doi: 10.1016/j.jacc.2015.07.051. J Am Coll Cardiol. 2015. PMID: 26403349 Free article. No abstract available.

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