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Smooth muscle phenotypic modulation is an early event in aortic aneurysms.
Ailawadi G, Moehle CW, Pei H, Walton SP, Yang Z, Kron IL, Lau CL, Owens GK. Ailawadi G, et al. Among authors: moehle cw. J Thorac Cardiovasc Surg. 2009 Dec;138(6):1392-9. doi: 10.1016/j.jtcvs.2009.07.075. J Thorac Cardiovasc Surg. 2009. PMID: 19931668 Free PMC article.
PDGF-DD, a novel mediator of smooth muscle cell phenotypic modulation, is upregulated in endothelial cells exposed to atherosclerosis-prone flow patterns.
Thomas JA, Deaton RA, Hastings NE, Shang Y, Moehle CW, Eriksson U, Topouzis S, Wamhoff BR, Blackman BR, Owens GK. Thomas JA, et al. Among authors: moehle cw. Am J Physiol Heart Circ Physiol. 2009 Feb;296(2):H442-52. doi: 10.1152/ajpheart.00165.2008. Epub 2008 Nov 21. Am J Physiol Heart Circ Physiol. 2009. PMID: 19028801 Free PMC article.