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Tissue transglutaminase is a negative regulator of monomeric lacritin bioactivity.
Velez V F, Romano JA, McKown RL, Green K, Zhang L, Raab RW, Ryan DS, Hutnik CM, Frierson HF Jr, Laurie GW. Velez V F, et al. Among authors: raab rw. Invest Ophthalmol Vis Sci. 2013 Mar 1;54(3):2123-32. doi: 10.1167/iovs.12-11488. Invest Ophthalmol Vis Sci. 2013. PMID: 23425695 Free PMC article.
Focus on molecules: lacritin.
Ma P, Wang N, McKown RL, Raab RW, Laurie GW. Ma P, et al. Among authors: raab rw. Exp Eye Res. 2008 Mar;86(3):457-8. doi: 10.1016/j.exer.2007.01.025. Epub 2007 Feb 16. Exp Eye Res. 2008. PMID: 17412322 Free PMC article. Review. No abstract available.
A cleavage-potentiated fragment of tear lacritin is bactericidal.
McKown RL, Coleman Frazier EV, Zadrozny KK, Deleault AM, Raab RW, Ryan DS, Sia RK, Lee JK, Laurie GW. McKown RL, et al. Among authors: raab rw. J Biol Chem. 2014 Aug 8;289(32):22172-82. doi: 10.1074/jbc.M114.570143. Epub 2014 Jun 18. J Biol Chem. 2014. PMID: 24942736 Free PMC article.
Focus on molecules: syndecan-1.
Zhang Y, McKown RL, Raab RW, Rapraeger AC, Laurie GW. Zhang Y, et al. Among authors: raab rw. Exp Eye Res. 2011 Oct;93(4):329-30. doi: 10.1016/j.exer.2010.06.008. Epub 2010 Jun 23. Exp Eye Res. 2011. PMID: 20599970 Free PMC article. No abstract available.
Targeting of heparanase-modified syndecan-1 by prosecretory mitogen lacritin requires conserved core GAGAL plus heparan and chondroitin sulfate as a novel hybrid binding site that enhances selectivity.
Zhang Y, Wang N, Raab RW, McKown RL, Irwin JA, Kwon I, van Kuppevelt TH, Laurie GW. Zhang Y, et al. Among authors: raab rw. J Biol Chem. 2013 Apr 26;288(17):12090-101. doi: 10.1074/jbc.M112.422717. Epub 2013 Mar 15. J Biol Chem. 2013. PMID: 23504321 Free PMC article.
Lacritin and other new proteins of the lacrimal functional unit.
McKown RL, Wang N, Raab RW, Karnati R, Zhang Y, Williams PB, Laurie GW. McKown RL, et al. Among authors: raab rw. Exp Eye Res. 2009 May;88(5):848-58. doi: 10.1016/j.exer.2008.09.002. Epub 2008 Sep 18. Exp Eye Res. 2009. PMID: 18840430 Free PMC article. Review.
25 results