Mariotti J - Search Results

1

Phase 2 clinical trial of rapamycin-resistant donor CD4+ Th2/Th1 (T-Rapa) cells after low-intensity allogeneic hematopoietic cell transplantation.

Fowler DH, Mossoba ME, Steinberg SM, Halverson DC, Stroncek D, Khuu HM, Hakim FT, Castiello L, Sabatino M, Leitman SF, Mariotti J, Gea-Banacloche JC, Sportes C, Hardy NM, Hickstein DD, Pavletic SZ, Rowley S, Goy A, Donato M, Korngold R, Pecora A, Levine BL, June CH, Gress RE, Bishop MR. Fowler DH, et al. Among authors: mariotti j. Blood. 2013 Apr 11;121(15):2864-74. doi: 10.1182/blood-2012-08-446872. Epub 2013 Feb 20. Blood. 2013. PMID: 23426943 Free PMC article. Clinical Trial.

2

Ex vivo rapamycin generates donor Th2 cells that potently inhibit graft-versus-host disease and graft-versus-tumor effects via an IL-4-dependent mechanism.

Foley JE, Jung U, Miera A, Borenstein T, Mariotti J, Eckhaus M, Bierer BE, Fowler DH. Foley JE, et al. Among authors: mariotti j. J Immunol. 2005 Nov 1;175(9):5732-43. doi: 10.4049/jimmunol.175.9.5732. J Immunol. 2005. PMID: 16237064

3

Ex vivo rapamycin generates Th1/Tc1 or Th2/Tc2 Effector T cells with enhanced in vivo function and differential sensitivity to post-transplant rapamycin therapy.

Jung U, Foley JE, Erdmann AA, Toda Y, Borenstein T, Mariotti J, Fowler DH. Jung U, et al. Among authors: mariotti j. Biol Blood Marrow Transplant. 2006 Sep;12(9):905-18. doi: 10.1016/j.bbmt.2006.05.014. Biol Blood Marrow Transplant. 2006. PMID: 16920556 Free article.

4

Ex vivo rapamycin generates apoptosis-resistant donor Th2 cells that persist in vivo and prevent hemopoietic stem cell graft rejection.

Mariotti J, Foley J, Jung U, Borenstein T, Kantardzic N, Han S, Hanson JT, Wong E, Buxhoeveden N, Trepel JB, Fojo AT, Telford W, Fowler DH. Mariotti J, et al. J Immunol. 2008 Jan 1;180(1):89-105. doi: 10.4049/jimmunol.180.1.89. J Immunol. 2008. PMID: 18097008

5

Rapamycin delays growth of Wnt-1 tumors in spite of suppression of host immunity.

Svirshchevskaya EV, Mariotti J, Wright MH, Viskova NY, Telford W, Fowler DH, Varticovski L. Svirshchevskaya EV, et al. Among authors: mariotti j. BMC Cancer. 2008 Jun 21;8:176. doi: 10.1186/1471-2407-8-176. BMC Cancer. 2008. PMID: 18570671 Free PMC article.

6

Graft rejection as a Th1-type process amenable to regulation by donor Th2-type cells through an interleukin-4/STAT6 pathway.

Mariotti J, Foley J, Ryan K, Buxhoeveden N, Kapoor V, Amarnath S, Fowler DH. Mariotti J, et al. Blood. 2008 Dec 1;112(12):4765-75. doi: 10.1182/blood-2008-05-154278. Epub 2008 Jul 14. Blood. 2008. PMID: 18625883 Free PMC article.

7

Th2 cell therapy of established acute graft-versus-host disease requires IL-4 and IL-10 and is abrogated by IL-2 or host-type antigen-presenting cells.

Foley JE, Mariotti J, Ryan K, Eckhaus M, Fowler DH. Foley JE, et al. Among authors: mariotti j. Biol Blood Marrow Transplant. 2008 Sep;14(9):959-972. doi: 10.1016/j.bbmt.2008.06.007. Biol Blood Marrow Transplant. 2008. PMID: 18721759 Free PMC article.

8

Potent induction of B- and T-cell immunity against human carcinoembryonic antigen-expressing tumors in human carcinoembryonic antigen transgenic mice mediated by direct lentivector injection.

Loisel-Meyer S, Felizardo T, Mariotti J, Mossoba ME, Foley JE, Kammerer R, Mizue N, Keefe R, McCart JA, Zimmermann W, Dropulic B, Fowler DH, Medin JA. Loisel-Meyer S, et al. Among authors: mariotti j. Mol Cancer Ther. 2009 Mar;8(3):692-702. doi: 10.1158/1535-7163.MCT-08-0769. Epub 2009 Mar 10. Mol Cancer Ther. 2009. PMID: 19276164 Free PMC article.

9

A central role for Foxp3+ regulatory T cells in K-Ras-driven lung tumorigenesis.

Granville CA, Memmott RM, Balogh A, Mariotti J, Kawabata S, Han W, Lopiccolo J, Foley J, Liewehr DJ, Steinberg SM, Fowler DH, Hollander MC, Dennis PA. Granville CA, et al. Among authors: mariotti j. PLoS One. 2009;4(3):e5061. doi: 10.1371/journal.pone.0005061. Epub 2009 Mar 30. PLoS One. 2009. PMID: 19330036 Free PMC article.

10

Regulatory T cells and human myeloid dendritic cells promote tolerance via programmed death ligand-1.

Amarnath S, Costanzo CM, Mariotti J, Ullman JL, Telford WG, Kapoor V, Riley JL, Levine BL, June CH, Fong T, Warner NL, Fowler DH. Amarnath S, et al. Among authors: mariotti j. PLoS Biol. 2010 Feb 2;8(2):e1000302. doi: 10.1371/journal.pbio.1000302. PLoS Biol. 2010. PMID: 20126379 Free PMC article.

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