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XRCC4 protein interactions with XRCC4-like factor (XLF) create an extended grooved scaffold for DNA ligation and double strand break repair.
Hammel M, Rey M, Yu Y, Mani RS, Classen S, Liu M, Pique ME, Fang S, Mahaney BL, Weinfeld M, Schriemer DC, Lees-Miller SP, Tainer JA. Hammel M, et al. Among authors: mahaney bl. J Biol Chem. 2011 Sep 16;286(37):32638-50. doi: 10.1074/jbc.M111.272641. Epub 2011 Jul 20. J Biol Chem. 2011. PMID: 21775435 Free PMC article.
Ku and DNA-dependent protein kinase dynamic conformations and assembly regulate DNA binding and the initial non-homologous end joining complex.
Hammel M, Yu Y, Mahaney BL, Cai B, Ye R, Phipps BM, Rambo RP, Hura GL, Pelikan M, So S, Abolfath RM, Chen DJ, Lees-Miller SP, Tainer JA. Hammel M, et al. Among authors: mahaney bl. J Biol Chem. 2010 Jan 8;285(2):1414-23. doi: 10.1074/jbc.M109.065615. Epub 2009 Nov 5. J Biol Chem. 2010. PMID: 19893054 Free PMC article.