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Effects of bezafibrate treatment in a patient and a carrier with mutations in the PNPLA2 gene, causing neutral lipid storage disease with myopathy.
van de Weijer T, Havekes B, Bilet L, Hoeks J, Sparks L, Bosma M, Paglialunga S, Jorgensen J, Janssen MC, Schaart G, Sauerwein H, Smeets JL, Wildberger J, Zechner R, Schrauwen-Hinderling VB, Hesselink MK, Schrauwen P. van de Weijer T, et al. Among authors: bosma m. Circ Res. 2013 Mar 1;112(5):e51-4. doi: 10.1161/CIRCRESAHA.113.300944. Circ Res. 2013. PMID: 23449549 No abstract available.
The lipid droplet coat protein perilipin 5 also localizes to muscle mitochondria.
Bosma M, Minnaard R, Sparks LM, Schaart G, Losen M, de Baets MH, Duimel H, Kersten S, Bickel PE, Schrauwen P, Hesselink MK. Bosma M, et al. Histochem Cell Biol. 2012 Feb;137(2):205-16. doi: 10.1007/s00418-011-0888-x. Epub 2011 Nov 30. Histochem Cell Biol. 2012. PMID: 22127648 Free PMC article.
One-leg inactivity induces a reduction in mitochondrial oxidative capacity, intramyocellular lipid accumulation and reduced insulin signalling upon lipid infusion: a human study with unilateral limb suspension.
Bilet L, Phielix E, van de Weijer T, Gemmink A, Bosma M, Moonen-Kornips E, Jorgensen JA, Schaart G, Zhang D, Meijer K, Hopman M, Hesselink MKC, Ouwens DM, Shulman GI, Schrauwen-Hinderling VB, Schrauwen P. Bilet L, et al. Among authors: bosma m. Diabetologia. 2020 Jun;63(6):1211-1222. doi: 10.1007/s00125-020-05128-1. Epub 2020 Mar 17. Diabetologia. 2020. PMID: 32185462 Free PMC article.
Augmenting muscle diacylglycerol and triacylglycerol content by blocking fatty acid oxidation does not impede insulin sensitivity.
Timmers S, Nabben M, Bosma M, van Bree B, Lenaers E, van Beurden D, Schaart G, Westerterp-Plantenga MS, Langhans W, Hesselink MK, Schrauwen-Hinderling VB, Schrauwen P. Timmers S, et al. Among authors: bosma m. Proc Natl Acad Sci U S A. 2012 Jul 17;109(29):11711-6. doi: 10.1073/pnas.1206868109. Epub 2012 Jul 2. Proc Natl Acad Sci U S A. 2012. PMID: 22753483 Free PMC article.
231 results