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Viral factors induce Hedgehog pathway activation in humans with viral hepatitis, cirrhosis, and hepatocellular carcinoma.
Pereira Tde A, Witek RP, Syn WK, Choi SS, Bradrick S, Karaca GF, Agboola KM, Jung Y, Omenetti A, Moylan CA, Yang L, Fernandez-Zapico ME, Jhaveri R, Shah VH, Pereira FE, Diehl AM. Pereira Tde A, et al. Among authors: yang l. Lab Invest. 2010 Dec;90(12):1690-703. doi: 10.1038/labinvest.2010.147. Epub 2010 Aug 9. Lab Invest. 2010. PMID: 20697376 Free PMC article.
Distinguishing between Hepatic Inflammation and Fibrosis with MR Elastography.
Yin M, Glaser KJ, Manduca A, Mounajjed T, Malhi H, Simonetto DA, Wang R, Yang L, Mao SA, Glorioso JM, Elgilani FM, Ward CJ, Harris PC, Nyberg SL, Shah VH, Ehman RL. Yin M, et al. Among authors: yang l. Radiology. 2017 Sep;284(3):694-705. doi: 10.1148/radiol.2017160622. Epub 2017 Jan 27. Radiology. 2017. PMID: 28128707 Free PMC article.
An Open-Label, Dose-Escalation Study to Assess the Safety and Efficacy of IL-22 Agonist F-652 in Patients With Alcohol-associated Hepatitis.
Arab JP, Sehrawat TS, Simonetto DA, Verma VK, Feng D, Tang T, Dreyer K, Yan X, Daley WL, Sanyal A, Chalasani N, Radaeva S, Yang L, Vargas H, Ibacache M, Gao B, Gores GJ, Malhi H, Kamath PS, Shah VH. Arab JP, et al. Among authors: yang l. Hepatology. 2020 Aug;72(2):441-453. doi: 10.1002/hep.31046. Epub 2020 Apr 27. Hepatology. 2020. PMID: 31774566 Free PMC article. Clinical Trial.
Smoothened is a master regulator of adult liver repair.
Michelotti GA, Xie G, Swiderska M, Choi SS, Karaca G, Krüger L, Premont R, Yang L, Syn WK, Metzger D, Diehl AM. Michelotti GA, et al. Among authors: yang l. J Clin Invest. 2013 Jun;123(6):2380-94. doi: 10.1172/JCI66904. J Clin Invest. 2013. PMID: 23563311 Free PMC article.
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