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Digestion products of the PH20 hyaluronidase inhibit remyelination.
Preston M, Gong X, Su W, Matsumoto SG, Banine F, Winkler C, Foster S, Xing R, Struve J, Dean J, Baggenstoss B, Weigel PH, Montine TJ, Back SA, Sherman LS. Preston M, et al. Among authors: weigel ph. Ann Neurol. 2013 Feb;73(2):266-80. doi: 10.1002/ana.23788. Epub 2013 Mar 5. Ann Neurol. 2013. PMID: 23463525 Free PMC article.
Hyaluronan synthase polymerizing activity and control of product size are discrete enzyme functions that can be uncoupled by mutagenesis of conserved cysteines.
Weigel PH, Baggenstoss BA. Weigel PH, et al. Glycobiology. 2012 Oct;22(10):1302-10. doi: 10.1093/glycob/cws102. Epub 2012 Jun 27. Glycobiology. 2012. PMID: 22745284 Free PMC article.
Previous studies of single Cys-to-Ser and all possible Cys-to-Ala mutants of SeHAS found that: the Cys-null mutant is active, Cys modification inhibits HAS activity and the conserved cysteines are clustered at the membrane-enzyme interface in substrate-binding sites (Kumari K, …
Previous studies of single Cys-to-Ser and all possible Cys-to-Ala mutants of SeHAS found that: the Cys-null mutant is active, Cys modificati …
Rat and human HARE/stabilin-2 are clearance receptors for high- and low-molecular-weight heparins.
Harris EN, Baggenstoss BA, Weigel PH. Harris EN, et al. Among authors: weigel ph. Am J Physiol Gastrointest Liver Physiol. 2009 Jun;296(6):G1191-9. doi: 10.1152/ajpgi.90717.2008. Epub 2009 Apr 9. Am J Physiol Gastrointest Liver Physiol. 2009. PMID: 19359419 Free PMC article.
The human hyaluronic acid (HA) receptor for endocytosis (HARE/stabilin-2) is the primary clearance receptor for systemic HA, chondroitin sulfates, and heparin, but not for heparan sulfate or keratan sulfate (Harris EN, Weigel JA, Weigel PH. J Biol Chem 283: 1 …
The human hyaluronic acid (HA) receptor for endocytosis (HARE/stabilin-2) is the primary clearance receptor for systemic HA, chondroitin sul …
169 results