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STING recognition of cytoplasmic DNA instigates cellular defense.
Abe T, Harashima A, Xia T, Konno H, Konno K, Morales A, Ahn J, Gutman D, Barber GN. Abe T, et al. Among authors: gutman d. Mol Cell. 2013 Apr 11;50(1):5-15. doi: 10.1016/j.molcel.2013.01.039. Epub 2013 Mar 7. Mol Cell. 2013. PMID: 23478444 Free PMC article.
STING manifests self DNA-dependent inflammatory disease.
Ahn J, Gutman D, Saijo S, Barber GN. Ahn J, et al. Among authors: gutman d. Proc Natl Acad Sci U S A. 2012 Nov 20;109(47):19386-91. doi: 10.1073/pnas.1215006109. Epub 2012 Nov 6. Proc Natl Acad Sci U S A. 2012. PMID: 23132945 Free PMC article.
Brucella abortus Triggers a cGAS-Independent STING Pathway To Induce Host Protection That Involves Guanylate-Binding Proteins and Inflammasome Activation.
Costa Franco MM, Marim F, Guimarães ES, Assis NRG, Cerqueira DM, Alves-Silva J, Harms J, Splitter G, Smith J, Kanneganti TD, de Queiroz NMGP, Gutman D, Barber GN, Oliveira SC. Costa Franco MM, et al. Among authors: gutman d. J Immunol. 2018 Jan 15;200(2):607-622. doi: 10.4049/jimmunol.1700725. Epub 2017 Dec 4. J Immunol. 2018. PMID: 29203515 Free PMC article.
Activation of STAT6 by STING is critical for antiviral innate immunity.
Chen H, Sun H, You F, Sun W, Zhou X, Chen L, Yang J, Wang Y, Tang H, Guan Y, Xia W, Gu J, Ishikawa H, Gutman D, Barber G, Qin Z, Jiang Z. Chen H, et al. Among authors: gutman d. Cell. 2011 Oct 14;147(2):436-46. doi: 10.1016/j.cell.2011.09.022. Cell. 2011. PMID: 22000020 Free article.
Brucella suppress STING expression via miR-24 to enhance infection.
Khan M, Harms JS, Liu Y, Eickhoff J, Tan JW, Hu T, Cai F, Guimaraes E, Oliveira SC, Dahl R, Cheng Y, Gutman D, Barber GN, Splitter GA, Smith JA. Khan M, et al. Among authors: gutman d. PLoS Pathog. 2020 Oct 27;16(10):e1009020. doi: 10.1371/journal.ppat.1009020. eCollection 2020 Oct. PLoS Pathog. 2020. PMID: 33108406 Free PMC article.
DENV inhibits type I IFN production in infected cells by cleaving human STING.
Aguirre S, Maestre AM, Pagni S, Patel JR, Savage T, Gutman D, Maringer K, Bernal-Rubio D, Shabman RS, Simon V, Rodriguez-Madoz JR, Mulder LC, Barber GN, Fernandez-Sesma A. Aguirre S, et al. Among authors: gutman d. PLoS Pathog. 2012;8(10):e1002934. doi: 10.1371/journal.ppat.1002934. Epub 2012 Oct 4. PLoS Pathog. 2012. PMID: 23055924 Free PMC article.
288 results