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Inhibition of TFG function causes hereditary axon degeneration by impairing endoplasmic reticulum structure.
Beetz C, Johnson A, Schuh AL, Thakur S, Varga RE, Fothergill T, Hertel N, Bomba-Warczak E, Thiele H, Nürnberg G, Altmüller J, Saxena R, Chapman ER, Dent EW, Nürnberg P, Audhya A. Beetz C, et al. Among authors: chapman er. Proc Natl Acad Sci U S A. 2013 Mar 26;110(13):5091-6. doi: 10.1073/pnas.1217197110. Epub 2013 Mar 11. Proc Natl Acad Sci U S A. 2013. PMID: 23479643 Free PMC article. Clinical Trial.
TFG regulates secretory and endosomal sorting pathways in neurons to promote their activity and maintenance.
Peotter JL, Pustova I, Lettman MM, Shatadal S, Bradberry MM, Winter-Reed AD, Charan M, Sharkey EE, Alvin JR, Bren AM, Oie AK, Chapman ER, Salamat MS, Audhya A. Peotter JL, et al. Among authors: chapman er. Proc Natl Acad Sci U S A. 2022 Oct 4;119(40):e2210649119. doi: 10.1073/pnas.2210649119. Epub 2022 Sep 26. Proc Natl Acad Sci U S A. 2022. PMID: 36161950 Free PMC article.
Pathogenic TFG Mutations Underlying Hereditary Spastic Paraplegia Impair Secretory Protein Trafficking and Axon Fasciculation.
Slosarek EL, Schuh AL, Pustova I, Johnson A, Bird J, Johnson M, Frankel EB, Bhattacharya N, Hanna MG, Burke JE, Ruhl DA, Quinney K, Block S, Peotter JL, Chapman ER, Sheets MD, Butcher SE, Stagg SM, Audhya A. Slosarek EL, et al. Among authors: chapman er. Cell Rep. 2018 Aug 28;24(9):2248-2260. doi: 10.1016/j.celrep.2018.07.081. Cell Rep. 2018. PMID: 30157421 Free PMC article.
Sar1 GTPase Activity Is Regulated by Membrane Curvature.
Hanna MG 4th, Mela I, Wang L, Henderson RM, Chapman ER, Edwardson JM, Audhya A. Hanna MG 4th, et al. Among authors: chapman er. J Biol Chem. 2016 Jan 15;291(3):1014-27. doi: 10.1074/jbc.M115.672287. Epub 2015 Nov 6. J Biol Chem. 2016. PMID: 26546679 Free PMC article.
Postsynaptic Neuroligin1 regulates presynaptic maturation.
Wittenmayer N, Körber C, Liu H, Kremer T, Varoqueaux F, Chapman ER, Brose N, Kuner T, Dresbach T. Wittenmayer N, et al. Among authors: chapman er. Proc Natl Acad Sci U S A. 2009 Aug 11;106(32):13564-9. doi: 10.1073/pnas.0905819106. Epub 2009 Jul 23. Proc Natl Acad Sci U S A. 2009. PMID: 19628693 Free PMC article.
200 results