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Targeting of heparanase-modified syndecan-1 by prosecretory mitogen lacritin requires conserved core GAGAL plus heparan and chondroitin sulfate as a novel hybrid binding site that enhances selectivity.
Zhang Y, Wang N, Raab RW, McKown RL, Irwin JA, Kwon I, van Kuppevelt TH, Laurie GW. Zhang Y, et al. Among authors: van kuppevelt th. J Biol Chem. 2013 Apr 26;288(17):12090-101. doi: 10.1074/jbc.M112.422717. Epub 2013 Mar 15. J Biol Chem. 2013. PMID: 23504321 Free PMC article.
The polybasic insertion in autotaxin α confers specific binding to heparin and cell surface heparan sulfate proteoglycans.
Houben AJ, van Wijk XM, van Meeteren LA, van Zeijl L, van de Westerlo EM, Hausmann J, Fish A, Perrakis A, van Kuppevelt TH, Moolenaar WH. Houben AJ, et al. Among authors: van wijk xm, van meeteren la, van kuppevelt th, van de westerlo em, van zeijl l. J Biol Chem. 2013 Jan 4;288(1):510-9. doi: 10.1074/jbc.M112.358416. Epub 2012 Nov 13. J Biol Chem. 2013. PMID: 23150666 Free PMC article.
357 results