Lewis SM - Search Results

1

Combined computational design of a zinc-binding site and a protein-protein interaction: one open zinc coordination site was not a robust hotspot for de novo ubiquitin binding.

Der BS, Jha RK, Lewis SM, Thompson PM, Guntas G, Kuhlman B. Der BS, et al. Among authors: lewis sm. Proteins. 2013 Jul;81(7):1245-55. doi: 10.1002/prot.24280. Epub 2013 Apr 20. Proteins. 2013. PMID: 23504819 Free PMC article.

2

Anchored design of protein-protein interfaces.

Lewis SM, Kuhlman BA. Lewis SM, et al. PLoS One. 2011;6(6):e20872. doi: 10.1371/journal.pone.0020872. Epub 2011 Jun 17. PLoS One. 2011. PMID: 21698112 Free PMC article.

3

Supertertiary structure of the MAGUK core from PSD-95.

Zhang J, Lewis SM, Kuhlman B, Lee AL. Zhang J, et al. Among authors: lewis sm. Structure. 2013 Mar 5;21(3):402-13. doi: 10.1016/j.str.2012.12.014. Epub 2013 Feb 7. Structure. 2013. PMID: 23395180 Free article.

4

Engineering a genetically encoded competitive inhibitor of the KEAP1-NRF2 interaction via structure-based design and phage display.

Guntas G, Lewis SM, Mulvaney KM, Cloer EW, Tripathy A, Lane TR, Major MB, Kuhlman B. Guntas G, et al. Among authors: lewis sm. Protein Eng Des Sel. 2016 Jan;29(1):1-9. doi: 10.1093/protein/gzv055. Epub 2015 Oct 20. Protein Eng Des Sel. 2016. PMID: 26489878 Free PMC article.

5

Mechanism of Lysine 48 Selectivity during Polyubiquitin Chain Formation by the Ube2R1/2 Ubiquitin-Conjugating Enzyme.

Hill S, Harrison JS, Lewis SM, Kuhlman B, Kleiger G. Hill S, et al. Among authors: lewis sm. Mol Cell Biol. 2016 May 16;36(11):1720-32. doi: 10.1128/MCB.00097-16. Print 2016 Jun 1. Mol Cell Biol. 2016. PMID: 27044868 Free PMC article.

6

Generation of bispecific IgG antibodies by structure-based design of an orthogonal Fab interface.

Lewis SM, Wu X, Pustilnik A, Sereno A, Huang F, Rick HL, Guntas G, Leaver-Fay A, Smith EM, Ho C, Hansen-Estruch C, Chamberlain AK, Truhlar SM, Conner EM, Atwell S, Kuhlman B, Demarest SJ. Lewis SM, et al. Nat Biotechnol. 2014 Feb;32(2):191-8. doi: 10.1038/nbt.2797. Epub 2014 Jan 26. Nat Biotechnol. 2014. PMID: 24463572

7

Ubiquitin-conjugating enzyme Cdc34 and ubiquitin ligase Skp1-cullin-F-box ligase (SCF) interact through multiple conformations.

Sandoval D, Hill S, Ziemba A, Lewis S, Kuhlman B, Kleiger G. Sandoval D, et al. J Biol Chem. 2015 Jan 9;290(2):1106-18. doi: 10.1074/jbc.M114.615559. Epub 2014 Nov 25. J Biol Chem. 2015. PMID: 25425648 Free PMC article.

8

Site-specific monoubiquitination activates Ras by impeding GTPase-activating protein function.

Baker R, Lewis SM, Sasaki AT, Wilkerson EM, Locasale JW, Cantley LC, Kuhlman B, Dohlman HG, Campbell SL. Baker R, et al. Among authors: lewis sm. Nat Struct Mol Biol. 2013 Jan;20(1):46-52. doi: 10.1038/nsmb.2430. Epub 2012 Nov 25. Nat Struct Mol Biol. 2013. PMID: 23178454 Free PMC article.

9

A biosensor generated via high-throughput screening quantifies cell edge Src dynamics.

Gulyani A, Vitriol E, Allen R, Wu J, Gremyachinskiy D, Lewis S, Dewar B, Graves LM, Kay BK, Kuhlman B, Elston T, Hahn KM. Gulyani A, et al. Nat Chem Biol. 2011 Jun 12;7(7):437-44. doi: 10.1038/nchembio.585. Nat Chem Biol. 2011. PMID: 21666688 Free PMC article.

10

Essential role for ubiquitin-ubiquitin-conjugating enzyme interaction in ubiquitin discharge from Cdc34 to substrate.

Saha A, Lewis S, Kleiger G, Kuhlman B, Deshaies RJ. Saha A, et al. Mol Cell. 2011 Apr 8;42(1):75-83. doi: 10.1016/j.molcel.2011.03.016. Mol Cell. 2011. PMID: 21474069 Free PMC article.

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