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Discovery of 2-aminothiazoles as potent antiprion compounds.
Ghaemmaghami S, May BC, Renslo AR, Prusiner SB. Ghaemmaghami S, et al. Among authors: renslo ar. J Virol. 2010 Apr;84(7):3408-12. doi: 10.1128/JVI.02145-09. Epub 2009 Dec 23. J Virol. 2010. PMID: 20032192 Free PMC article.
2-Aminothiazoles as therapeutic leads for prion diseases.
Gallardo-Godoy A, Gever J, Fife KL, Silber BM, Prusiner SB, Renslo AR. Gallardo-Godoy A, et al. Among authors: renslo ar. J Med Chem. 2011 Feb 24;54(4):1010-21. doi: 10.1021/jm101250y. Epub 2011 Jan 19. J Med Chem. 2011. PMID: 21247166 Free PMC article.
Predicting binding to p-glycoprotein by flexible receptor docking.
Dolghih E, Bryant C, Renslo AR, Jacobson MP. Dolghih E, et al. Among authors: renslo ar. PLoS Comput Biol. 2011 Jun;7(6):e1002083. doi: 10.1371/journal.pcbi.1002083. Epub 2011 Jun 23. PLoS Comput Biol. 2011. PMID: 21731480 Free PMC article.
Chemical-biological characterization of a cruzain inhibitor reveals a second target and a mammalian off-target.
Choy JW, Bryant C, Calvet CM, Doyle PS, Gunatilleke SS, Leung SS, Ang KK, Chen S, Gut J, Oses-Prieto JA, Johnston JB, Arkin MR, Burlingame AL, Taunton J, Jacobson MP, McKerrow JM, Podust LM, Renslo AR. Choy JW, et al. Among authors: renslo ar. Beilstein J Org Chem. 2013;9:15-25. doi: 10.3762/bjoc.9.3. Epub 2013 Jan 4. Beilstein J Org Chem. 2013. PMID: 23400640 Free PMC article.
Pharmacokinetics and metabolism of 2-aminothiazoles with antiprion activity in mice.
Silber BM, Rao S, Fife KL, Gallardo-Godoy A, Renslo AR, Dalvie DK, Giles K, Freyman Y, Elepano M, Gever JR, Li Z, Jacobson MP, Huang Y, Benet LZ, Prusiner SB. Silber BM, et al. Among authors: renslo ar. Pharm Res. 2013 Apr;30(4):932-50. doi: 10.1007/s11095-012-0912-4. Epub 2013 Feb 16. Pharm Res. 2013. PMID: 23417511 Free PMC article.
120 results