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Immunofluorescent spectral analysis reveals the intrathecal cannabinoid agonist, AM1241, produces spinal anti-inflammatory cytokine responses in neuropathic rats exhibiting relief from allodynia.
Wilkerson JL, Gentry KR, Dengler EC, Wallace JA, Kerwin AA, Kuhn MN, Zvonok AM, Thakur GA, Makriyannis A, Milligan ED. Wilkerson JL, et al. Among authors: dengler ec. Brain Behav. 2012 Mar;2(2):155-77. doi: 10.1002/brb3.44. Brain Behav. 2012. PMID: 22574283 Free PMC article.
Release of plasmid DNA-encoding IL-10 from PLGA microparticles facilitates long-term reversal of neuropathic pain following a single intrathecal administration.
Soderquist RG, Sloane EM, Loram LC, Harrison JA, Dengler EC, Johnson SM, Amer LD, Young CS, Lewis MT, Poole S, Frank MG, Watkins LR, Milligan ED, Mahoney MJ. Soderquist RG, et al. Among authors: dengler ec. Pharm Res. 2010 May;27(5):841-54. doi: 10.1007/s11095-010-0077-y. Epub 2010 Mar 12. Pharm Res. 2010. PMID: 20224990 Free PMC article.