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Peripherally administered cannabinoid receptor 2 (CB2R) agonists lose anti-allodynic effects in TRPV1 knockout mice, while intrathecal administration leads to anti-allodynia and reduced GFAP, CCL2 and TRPV1 expression in the dorsal spinal cord and DRG.
Wilkerson JL, Alberti LB, Thakur GA, Makriyannis A, Milligan ED. Wilkerson JL, et al. Among authors: milligan ed. Brain Res. 2022 Jan 1;1774:147721. doi: 10.1016/j.brainres.2021.147721. Epub 2021 Nov 10. Brain Res. 2022. PMID: 34774500 Free PMC article.
Immunofluorescent spectral analysis reveals the intrathecal cannabinoid agonist, AM1241, produces spinal anti-inflammatory cytokine responses in neuropathic rats exhibiting relief from allodynia.
Wilkerson JL, Gentry KR, Dengler EC, Wallace JA, Kerwin AA, Kuhn MN, Zvonok AM, Thakur GA, Makriyannis A, Milligan ED. Wilkerson JL, et al. Among authors: milligan ed. Brain Behav. 2012 Mar;2(2):155-77. doi: 10.1002/brb3.44. Brain Behav. 2012. PMID: 22574283 Free PMC article.
Release of plasmid DNA-encoding IL-10 from PLGA microparticles facilitates long-term reversal of neuropathic pain following a single intrathecal administration.
Soderquist RG, Sloane EM, Loram LC, Harrison JA, Dengler EC, Johnson SM, Amer LD, Young CS, Lewis MT, Poole S, Frank MG, Watkins LR, Milligan ED, Mahoney MJ. Soderquist RG, et al. Among authors: milligan ed. Pharm Res. 2010 May;27(5):841-54. doi: 10.1007/s11095-010-0077-y. Epub 2010 Mar 12. Pharm Res. 2010. PMID: 20224990 Free PMC article.
Spinal interleukin-10 therapy to treat peripheral neuropathic pain.
Milligan ED, Penzkover KR, Soderquist RG, Mahoney MJ. Milligan ED, et al. Neuromodulation. 2012 Nov-Dec;15(6):520-6; discussion 526. doi: 10.1111/j.1525-1403.2012.00462.x. Epub 2012 Jun 1. Neuromodulation. 2012. PMID: 22672183 Free PMC article. Review.
Effects of spinal non-viral interleukin-10 gene therapy formulated with d-mannose in neuropathic interleukin-10 deficient mice: Behavioral characterization, mRNA and protein analysis in pain relevant tissues.
Vanderwall AG, Noor S, Sun MS, Sanchez JE, Yang XO, Jantzie LL, Mellios N, Milligan ED. Vanderwall AG, et al. Among authors: milligan ed. Brain Behav Immun. 2018 Mar;69:91-112. doi: 10.1016/j.bbi.2017.11.004. Epub 2017 Nov 4. Brain Behav Immun. 2018. PMID: 29113923 Free PMC article.
80 results