Grütter C - Search Results

1

Selective detection of allosteric phosphatase inhibitors.

Schneider R, Beumer C, Simard JR, Grütter C, Rauh D. Schneider R, et al. Among authors: grutter c. J Am Chem Soc. 2013 May 8;135(18):6838-41. doi: 10.1021/ja4030484. Epub 2013 Apr 26. J Am Chem Soc. 2013. PMID: 23611635

2

Structural insights into how irreversible inhibitors can overcome drug resistance in EGFR.

Michalczyk A, Klüter S, Rode HB, Simard JR, Grütter C, Rabiller M, Rauh D. Michalczyk A, et al. Among authors: grutter c. Bioorg Med Chem. 2008 Apr 1;16(7):3482-8. doi: 10.1016/j.bmc.2008.02.053. Epub 2008 Feb 20. Bioorg Med Chem. 2008. PMID: 18316192

3

A new screening assay for allosteric inhibitors of cSrc.

Simard JR, Klüter S, Grütter C, Getlik M, Rabiller M, Rode HB, Rauh D. Simard JR, et al. Among authors: grutter c. Nat Chem Biol. 2009 Jun;5(6):394-6. doi: 10.1038/nchembio.162. Epub 2009 Apr 26. Nat Chem Biol. 2009. PMID: 19396179

4

Development of a fluorescent-tagged kinase assay system for the detection and characterization of allosteric kinase inhibitors.

Simard JR, Getlik M, Grütter C, Pawar V, Wulfert S, Rabiller M, Rauh D. Simard JR, et al. Among authors: grutter c. J Am Chem Soc. 2009 Sep 23;131(37):13286-96. doi: 10.1021/ja902010p. J Am Chem Soc. 2009. PMID: 19572644

5

Displacement assay for the detection of stabilizers of inactive kinase conformations.

Klüter S, Grütter C, Naqvi T, Rabiller M, Simard JR, Pawar V, Getlik M, Rauh D. Klüter S, et al. Among authors: grutter c. J Med Chem. 2010 Jan 14;53(1):357-67. doi: 10.1021/jm901297e. J Med Chem. 2010. PMID: 19928858

6

High-throughput screening to identify inhibitors which stabilize inactive kinase conformations in p38alpha.

Simard JR, Grütter C, Pawar V, Aust B, Wolf A, Rabiller M, Wulfert S, Robubi A, Klüter S, Ottmann C, Rauh D. Simard JR, et al. Among authors: grutter c. J Am Chem Soc. 2009 Dec 30;131(51):18478-88. doi: 10.1021/ja907795q. J Am Chem Soc. 2009. PMID: 19950957

7

Fluorophore labeling of the glycine-rich loop as a method of identifying inhibitors that bind to active and inactive kinase conformations.

Simard JR, Getlik M, Grütter C, Schneider R, Wulfert S, Rauh D. Simard JR, et al. Among authors: grutter c. J Am Chem Soc. 2010 Mar 31;132(12):4152-60. doi: 10.1021/ja908083e. J Am Chem Soc. 2010. PMID: 20201574

8

Characterization of irreversible kinase inhibitors by directly detecting covalent bond formation: a tool for dissecting kinase drug resistance.

Klüter S, Simard JR, Rode HB, Grütter C, Pawar V, Raaijmakers HC, Barf TA, Rabiller M, van Otterlo WA, Rauh D. Klüter S, et al. Among authors: grutter c. Chembiochem. 2010 Dec 10;11(18):2557-66. doi: 10.1002/cbic.201000352. Chembiochem. 2010. PMID: 21080395

9

Identification of Ustilago maydis Aurora kinase as a novel antifungal target.

Tückmantel S, Greul JN, Janning P, Brockmeyer A, Grütter C, Simard JR, Gutbrod O, Beck ME, Tietjen K, Rauh D, Schreier PH. Tückmantel S, et al. Among authors: grutter c. ACS Chem Biol. 2011 Sep 16;6(9):926-33. doi: 10.1021/cb200112y. Epub 2011 Jun 20. ACS Chem Biol. 2011. PMID: 21671622

10

Strategies for the selective regulation of kinases with allosteric modulators: exploiting exclusive structural features.

Fang Z, Grütter C, Rauh D. Fang Z, et al. Among authors: grutter c. ACS Chem Biol. 2013 Jan 18;8(1):58-70. doi: 10.1021/cb300663j. Epub 2012 Dec 31. ACS Chem Biol. 2013. PMID: 23249378 Review.

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