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Improved cell therapy protocols for Parkinson's disease based on differentiation efficiency and safety of hESC-, hiPSC-, and non-human primate iPSC-derived dopaminergic neurons.
Sundberg M, Bogetofte H, Lawson T, Jansson J, Smith G, Astradsson A, Moore M, Osborn T, Cooper O, Spealman R, Hallett P, Isacson O. Sundberg M, et al. Among authors: hallett p. Stem Cells. 2013 Aug;31(8):1548-62. doi: 10.1002/stem.1415. Stem Cells. 2013. PMID: 23666606 Free PMC article.
Inhibition of the dopamine D1 receptor signaling by PSD-95.
Zhang J, Vinuela A, Neely MH, Hallett PJ, Grant SG, Miller GM, Isacson O, Caron MG, Yao WD. Zhang J, et al. J Biol Chem. 2007 May 25;282(21):15778-89. doi: 10.1074/jbc.M611485200. Epub 2007 Mar 16. J Biol Chem. 2007. PMID: 17369255 Free PMC article.
No evidence for disease-like processes in fetal transplants.
Hallett PJ, Cooper O, Isacson O. Hallett PJ, et al. Proc Natl Acad Sci U S A. 2009 Sep 15;106(37):E104; author reply E105. doi: 10.1073/pnas.0908169106. Epub 2009 Sep 2. Proc Natl Acad Sci U S A. 2009. PMID: 19805203 Free PMC article. No abstract available.
Differentiated Parkinson patient-derived induced pluripotent stem cells grow in the adult rodent brain and reduce motor asymmetry in Parkinsonian rats.
Hargus G, Cooper O, Deleidi M, Levy A, Lee K, Marlow E, Yow A, Soldner F, Hockemeyer D, Hallett PJ, Osborn T, Jaenisch R, Isacson O. Hargus G, et al. Proc Natl Acad Sci U S A. 2010 Sep 7;107(36):15921-6. doi: 10.1073/pnas.1010209107. Epub 2010 Aug 23. Proc Natl Acad Sci U S A. 2010. PMID: 20798034 Free PMC article.
142 results