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Functional genomics identifies five distinct molecular subtypes with clinical relevance and pathways for growth control in epithelial ovarian cancer.
Tan TZ, Miow QH, Huang RY, Wong MK, Ye J, Lau JA, Wu MC, Bin Abdul Hadi LH, Soong R, Choolani M, Davidson B, Nesland JM, Wang LZ, Matsumura N, Mandai M, Konishi I, Goh BC, Chang JT, Thiery JP, Mori S. Tan TZ, et al. Among authors: choolani m. EMBO Mol Med. 2013 Jul;5(7):1051-66. doi: 10.1002/emmm.201201823. Epub 2013 May 13. EMBO Mol Med. 2013. PMID: 23666744 Free PMC article.
RUNX3 functions as an oncogene in ovarian cancer.
Lee CW, Chuang LS, Kimura S, Lai SK, Ong CW, Yan B, Salto-Tellez M, Choolani M, Ito Y. Lee CW, et al. Among authors: choolani m. Gynecol Oncol. 2011 Aug;122(2):410-7. doi: 10.1016/j.ygyno.2011.04.044. Epub 2011 May 25. Gynecol Oncol. 2011. PMID: 21612813
An EMT spectrum defines an anoikis-resistant and spheroidogenic intermediate mesenchymal state that is sensitive to e-cadherin restoration by a src-kinase inhibitor, saracatinib (AZD0530).
Huang RY, Wong MK, Tan TZ, Kuay KT, Ng AH, Chung VY, Chu YS, Matsumura N, Lai HC, Lee YF, Sim WJ, Chai C, Pietschmann E, Mori S, Low JJ, Choolani M, Thiery JP. Huang RY, et al. Among authors: choolani m. Cell Death Dis. 2013 Nov 7;4(11):e915. doi: 10.1038/cddis.2013.442. Cell Death Dis. 2013. PMID: 24201814 Free PMC article.
248 results