Doyle ML - Search Results

1

Application of a kosmotrope-based solubility assay to multiple protein therapeutic classes indicates broad use as a high-throughput screen for protein therapeutic aggregation propensity.

Yamniuk AP, Ditto N, Patel M, Dai J, Sejwal P, Stetsko P, Doyle ML. Yamniuk AP, et al. Among authors: doyle ml. J Pharm Sci. 2013 Aug;102(8):2424-39. doi: 10.1002/jps.23618. Epub 2013 May 27. J Pharm Sci. 2013. PMID: 23712759

2

Comparison of Ensemble and Single Molecule Methods for Particle Characterization and Binding Analysis of a PEGylated Single-Domain Antibody.

Schneeweis LA, Obenauer-Kutner L, Kaur P, Yamniuk AP, Tamura J, Jaffe N, O'Mara BW, Lindsay S, Doyle M, Bryson J. Schneeweis LA, et al. J Pharm Sci. 2015 Dec;104(12):4015-4024. doi: 10.1002/jps.24624. Epub 2015 Sep 7. J Pharm Sci. 2015. PMID: 26343417

3

ABRF-MIRG benchmark study: molecular interactions in a three-component system.

Yamniuk AP, Edavettal SC, Bergqvist S, Yadav SP, Doyle ML, Calabrese K, Parsons JF, Eisenstein E. Yamniuk AP, et al. Among authors: doyle ml. J Biomol Tech. 2012 Sep;23(3):101-14. doi: 10.7171/jbt.12-2303-003. J Biomol Tech. 2012. PMID: 22942790 Free PMC article.

4

A fibronectin scaffold approach to bispecific inhibitors of epidermal growth factor receptor and insulin-like growth factor-I receptor.

Emanuel SL, Engle LJ, Chao G, Zhu RR, Cao C, Lin Z, Yamniuk AP, Hosbach J, Brown J, Fitzpatrick E, Gokemeijer J, Morin P, Morse BA, Carvajal IM, Fabrizio D, Wright MC, Das Gupta R, Gosselin M, Cataldo D, Ryseck RP, Doyle ML, Wong TW, Camphausen RT, Cload ST, Marsh HN, Gottardis MM, Furfine ES. Emanuel SL, et al. Among authors: doyle ml. MAbs. 2011 Jan-Feb;3(1):38-48. doi: 10.4161/mabs.3.1.14168. Epub 2011 Jan 1. MAbs. 2011. PMID: 21099371 Free PMC article.

5

Reversible and pH-dependent weak drug-excipient binding does not affect oral bioavailability of high dose drugs.

Narang AS, Yamniuk AP, Zhang L, Comezoglu SN, Bindra DS, Varia S, Doyle ML, Badawy S. Narang AS, et al. Among authors: doyle ml. J Pharm Pharmacol. 2012 Apr;64(4):553-65. doi: 10.1111/j.2042-7158.2011.01435.x. Epub 2012 Jan 13. J Pharm Pharmacol. 2012. PMID: 22420661

6

The structure of the death receptor 4-TNF-related apoptosis-inducing ligand (DR4-TRAIL) complex.

Ramamurthy V, Yamniuk AP, Lawrence EJ, Yong W, Schneeweis LA, Cheng L, Murdock M, Corbett MJ, Doyle ML, Sheriff S. Ramamurthy V, et al. Among authors: doyle ml. Acta Crystallogr F Struct Biol Commun. 2015 Oct;71(Pt 10):1273-81. doi: 10.1107/S2053230X15016416. Epub 2015 Sep 23. Acta Crystallogr F Struct Biol Commun. 2015. PMID: 26457518 Free PMC article.

7

Development of a Model Protein Interaction Pair as a Benchmarking Tool for the Quantitative Analysis of 2-Site Protein-Protein Interactions.

Yamniuk AP, Newitt JA, Doyle ML, Arisaka F, Giannetti AM, Hensley P, Myszka DG, Schwarz FP, Thomson JA, Eisenstein E. Yamniuk AP, et al. Among authors: doyle ml. J Biomol Tech. 2015 Dec;26(4):125-41. doi: 10.7171/jbt.15-2604-001. Epub 2015 Oct 29. J Biomol Tech. 2015. PMID: 26543437 Free PMC article.

8

MIRG Survey 2011: snapshot of rapidly evolving label-free technologies used for characterizing molecular interactions.

Yadav SP, Bergqvist S, Doyle ML, Neubert TA, Yamniuk AP. Yadav SP, et al. Among authors: doyle ml. J Biomol Tech. 2012 Sep;23(3):94-100. doi: 10.7171/jbt.12-2303-002. J Biomol Tech. 2012. PMID: 22942789 Free PMC article.

9

Structural mass spectrometry in protein therapeutics discovery.

Kim YJ, Doyle ML. Kim YJ, et al. Among authors: doyle ml. Anal Chem. 2010 Sep 1;82(17):7083-9. doi: 10.1021/ac101575d. Anal Chem. 2010. PMID: 20698501

10

Assessing compound binding to the Eg5 motor domain using a thermal shift assay.

McDonnell PA, Yanchunas J, Newitt JA, Tao L, Kiefer SE, Ortega M, Kut S, Burford N, Goldfarb V, Duke GJ, Shen H, Metzler W, Doyle M, Chen Z, Tarby C, Borzilleri R, Vaccaro W, Gottardis M, Lu S, Crews D, Kim K, Lombardo L, Roussell DL. McDonnell PA, et al. Anal Biochem. 2009 Sep 1;392(1):59-69. doi: 10.1016/j.ab.2009.05.044. Epub 2009 Jun 2. Anal Biochem. 2009. PMID: 19497292

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