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Discovery of high potency, single-chain insulin analogs with a shortened B-chain and nonpeptide linker.
ACS Chem Biol. 2013 Aug 16;8(8):1822-9. doi: 10.1021/cb4002624. Epub 2013 Jun 18.
ACS Chem Biol. 2013.
PMID: 23730814
Synthesis and pharmacological evaluation of N-(3-(1H-indol-4-yl)-5-(2-methoxyisonicotinoyl)phenyl)methanesulfonamide (LP-261), a potent antimitotic agent.
Shetty RS, Lee Y, Liu B, Husain A, Joseph RW, Lu Y, Nelson D, Mihelcic J, Chao W, Moffett KK, Schumacher A, Flubacher D, Stojanovic A, Bukhtiyarova M, Williams K, Lee KJ, Ochman AR, Saporito MS, Moore WR, Flynn GA, Dorsey BD, Springman EB, Fujimoto T, Kelly MJ.
Shetty RS, et al. Among authors: ochman ar.
J Med Chem. 2011 Jan 13;54(1):179-200. doi: 10.1021/jm100659v. Epub 2010 Dec 2.
J Med Chem. 2011.
PMID: 21126027
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MLR-1023 is a potent and selective allosteric activator of Lyn kinase in vitro that improves glucose tolerance in vivo.
Saporito MS, Ochman AR, Lipinski CA, Handler JA, Reaume AG.
Saporito MS, et al. Among authors: ochman ar.
J Pharmacol Exp Ther. 2012 Jul;342(1):15-22. doi: 10.1124/jpet.112.192096. Epub 2012 Apr 3.
J Pharmacol Exp Ther. 2012.
PMID: 22473614
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The Lyn kinase activator MLR-1023 is a novel insulin receptor potentiator that elicits a rapid-onset and durable improvement in glucose homeostasis in animal models of type 2 diabetes.
Ochman AR, Lipinski CA, Handler JA, Reaume AG, Saporito MS.
Ochman AR, et al.
J Pharmacol Exp Ther. 2012 Jul;342(1):23-32. doi: 10.1124/jpet.112.192187. Epub 2012 Mar 19.
J Pharmacol Exp Ther. 2012.
PMID: 22431203
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Inappropriate shock caused by P- and T-wave oversensing in a subcutaneous implantable cardiac defibrillator in a patient in sinus rhythm.
Ochman AR, Riesbeck M, Corbisiero R.
Ochman AR, et al.
HeartRhythm Case Rep. 2020 Dec 5;7(7):433-435. doi: 10.1016/j.hrcr.2020.11.022. eCollection 2021 Jul.
HeartRhythm Case Rep. 2020.
PMID: 34307022
Free PMC article.
No abstract available.
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Characterization of a carcinogenesis rat model of ovarian preneoplasia and neoplasia.
Stewart SL, Querec TD, Ochman AR, Gruver BN, Bao R, Babb JS, Wong TS, Koutroukides T, Pinnola AD, Klein-Szanto A, Hamilton TC, Patriotis C.
Stewart SL, et al. Among authors: ochman ar.
Cancer Res. 2004 Nov 15;64(22):8177-83. doi: 10.1158/0008-5472.CAN-04-1702.
Cancer Res. 2004.
PMID: 15548682
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