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Amygdala-dependent fear is regulated by Oprl1 in mice and humans with PTSD.
Andero R, Brothers SP, Jovanovic T, Chen YT, Salah-Uddin H, Cameron M, Bannister TD, Almli L, Stevens JS, Bradley B, Binder EB, Wahlestedt C, Ressler KJ. Andero R, et al. Among authors: ressler kj. Sci Transl Med. 2013 Jun 5;5(188):188ra73. doi: 10.1126/scitranslmed.3005656. Sci Transl Med. 2013. PMID: 23740899 Free PMC article.
Impaired fear inhibition is a biomarker of PTSD but not depression.
Jovanovic T, Norrholm SD, Blanding NQ, Davis M, Duncan E, Bradley B, Ressler KJ. Jovanovic T, et al. Among authors: ressler kj. Depress Anxiety. 2010 Mar;27(3):244-51. doi: 10.1002/da.20663. Depress Anxiety. 2010. PMID: 20143428 Free PMC article.
507 results