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12-lipoxygenase activity plays an important role in PAR4 and GPVI-mediated platelet reactivity.
Thromb Haemost. 2013 Sep;110(3):569-81. doi: 10.1160/TH13-01-0014. Epub 2013 Jun 20.
Thromb Haemost. 2013.
PMID: 23784669
Free PMC article.
Protease-activated receptor signaling in platelets activates cytosolic phospholipase A2α differently for cyclooxygenase-1 and 12-lipoxygenase catalysis.
Holinstat M, Boutaud O, Apopa PL, Vesci J, Bala M, Oates JA, Hamm HE.
Holinstat M, et al. Among authors: vesci j.
Arterioscler Thromb Vasc Biol. 2011 Feb;31(2):435-42. doi: 10.1161/ATVBAHA.110.219527. Epub 2010 Dec 2.
Arterioscler Thromb Vasc Biol. 2011.
PMID: 21127289
Free PMC article.
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Protein kinase C regulation of 12-lipoxygenase-mediated human platelet activation.
Yeung J, Apopa PL, Vesci J, Kenyon V, Rai G, Jadhav A, Simeonov A, Holman TR, Maloney DJ, Boutaud O, Holinstat M.
Yeung J, et al. Among authors: vesci j.
Mol Pharmacol. 2012 Mar;81(3):420-30. doi: 10.1124/mol.111.075630. Epub 2011 Dec 9.
Mol Pharmacol. 2012.
PMID: 22155783
Free PMC article.
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Platelet 12-LOX is essential for FcγRIIa-mediated platelet activation.
Yeung J, Tourdot BE, Fernandez-Perez P, Vesci J, Ren J, Smyrniotis CJ, Luci DK, Jadhav A, Simeonov A, Maloney DJ, Holman TR, McKenzie SE, Holinstat M.
Yeung J, et al. Among authors: vesci j.
Blood. 2014 Oct 2;124(14):2271-9. doi: 10.1182/blood-2014-05-575878. Epub 2014 Aug 6.
Blood. 2014.
PMID: 25100742
Free PMC article.
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The protease-activated receptor 4 Ala120Thr variant alters platelet responsiveness to low-dose thrombin and protease-activated receptor 4 desensitization, and is blocked by non-competitive P2Y12 inhibition.
Whitley MJ, Henke DM, Ghazi A, Nieman M, Stoller M, Simon LM, Chen E, Vesci J, Holinstat M, McKenzie SE, Shaw CA, Edelstein LC, Bray PF.
Whitley MJ, et al. Among authors: vesci j.
J Thromb Haemost. 2018 Dec;16(12):2501-2514. doi: 10.1111/jth.14318. Epub 2018 Nov 22.
J Thromb Haemost. 2018.
PMID: 30347494
Free PMC article.
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Investigations of human platelet-type 12-lipoxygenase: role of lipoxygenase products in platelet activation.
Ikei KN, Yeung J, Apopa PL, Ceja J, Vesci J, Holman TR, Holinstat M.
Ikei KN, et al. Among authors: vesci j.
J Lipid Res. 2012 Dec;53(12):2546-59. doi: 10.1194/jlr.M026385. Epub 2012 Sep 13.
J Lipid Res. 2012.
PMID: 22984144
Free PMC article.
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Platelet concentrate effects on thromboelastography.
McNulty SE, Sasso P, Vesci J, Schieren H.
McNulty SE, et al. Among authors: vesci j.
J Cardiothorac Vasc Anesth. 1997 Dec;11(7):828-30. doi: 10.1016/s1053-0770(97)90114-2.
J Cardiothorac Vasc Anesth. 1997.
PMID: 9412878
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