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Loss of function studies in mice and genetic association link receptor protein tyrosine phosphatase α to schizophrenia.
Takahashi N, Nielsen KS, Aleksic B, Petersen S, Ikeda M, Kushima I, Vacaresse N, Ujike H, Iwata N, Dubreuil V, Mirza N, Sakurai T, Ozaki N, Buxbaum JD, Sap J. Takahashi N, et al. Among authors: sap j. Biol Psychiatry. 2011 Oct 1;70(7):626-35. doi: 10.1016/j.biopsych.2011.06.016. Epub 2011 Aug 10. Biol Psychiatry. 2011. PMID: 21831360 Free PMC article.
Loss-of-function of PTPR γ and ζ, observed in sporadic schizophrenia, causes brain region-specific deregulation of monoamine levels and altered behavior in mice.
Cressant A, Dubreuil V, Kong J, Kranz TM, Lazarini F, Launay JM, Callebert J, Sap J, Malaspina D, Granon S, Harroch S. Cressant A, et al. Among authors: sap j. Psychopharmacology (Berl). 2017 Feb;234(4):575-587. doi: 10.1007/s00213-016-4490-8. Epub 2016 Dec 26. Psychopharmacology (Berl). 2017. PMID: 28025742
Protein tyrosine phosphatase-α amplifies transforming growth factor-β-dependent profibrotic signaling in lung fibroblasts.
Aschner Y, Nelson M, Brenner M, Roybal H, Beke K, Meador C, Foster D, Correll KA, Reynolds PR, Anderson K, Redente EF, Matsuda J, Riches DWH, Groshong SD, Pozzi A, Sap J, Wang Q, Rajshankar D, McCulloch CAG, Zemans RL, Downey GP. Aschner Y, et al. Among authors: sap j. Am J Physiol Lung Cell Mol Physiol. 2020 Aug 1;319(2):L294-L311. doi: 10.1152/ajplung.00235.2019. Epub 2020 Jun 3. Am J Physiol Lung Cell Mol Physiol. 2020. PMID: 32491951 Free PMC article.
Protein tyrosine phosphatase α mediates profibrotic signaling in lung fibroblasts through TGF-β responsiveness.
Aschner Y, Khalifah AP, Briones N, Yamashita C, Dolgonos L, Young SK, Campbell MN, Riches DW, Redente EF, Janssen WJ, Henson PM, Sap J, Vacaresse N, Kapus A, McCulloch CA, Zemans RL, Downey GP. Aschner Y, et al. Among authors: sap j. Am J Pathol. 2014 May;184(5):1489-502. doi: 10.1016/j.ajpath.2014.01.016. Epub 2014 Mar 17. Am J Pathol. 2014. PMID: 24650563 Free PMC article.
67 results