Kerns RJ - Search Results

1

Selective inhibition of bacterial and human topoisomerases by N-arylacyl O-sulfonated aminoglycoside derivatives.

Fenner AM, Oppegard LM, Hiasa H, Kerns RJ. Fenner AM, et al. Among authors: kerns rj. ACS Med Chem Lett. 2013 May 9;4(5):470-474. doi: 10.1021/ml3004507. ACS Med Chem Lett. 2013. PMID: 23814643 Free PMC article.

2

Diversity-oriented chemical modification of heparin: Identification of charge-reduced N-acyl heparin derivatives having increased selectivity for heparin-binding proteins.

Huang L, Kerns RJ. Huang L, et al. Among authors: kerns rj. Bioorg Med Chem. 2006 Apr 1;14(7):2300-13. doi: 10.1016/j.bmc.2005.11.013. Epub 2005 Nov 28. Bioorg Med Chem. 2006. PMID: 16314105

3

Different protein-binding selectivities for N-acyl heparin derivatives having N-phenylacetyl and heterocycle analogs of N-phenylacetyl substituted in place of N-sulfo groups.

Huang L, Fernández C, Kerns RJ. Huang L, et al. Among authors: kerns rj. Bioorg Med Chem Lett. 2007 Jan 15;17(2):419-23. doi: 10.1016/j.bmcl.2006.10.026. Epub 2006 Oct 17. Bioorg Med Chem Lett. 2007. PMID: 17070049

4

Quinolones: action and resistance updated.

Drlica K, Hiasa H, Kerns R, Malik M, Mustaev A, Zhao X. Drlica K, et al. Curr Top Med Chem. 2009;9(11):981-98. doi: 10.2174/156802609789630947. Curr Top Med Chem. 2009. PMID: 19747119 Free PMC article. Review.

5

Comparison of in vitro activities of fluoroquinolone-like 2,4- and 1,3-diones.

Oppegard LM, Streck KR, Rosen JD, Schwanz HA, Drlica K, Kerns RJ, Hiasa H. Oppegard LM, et al. Among authors: kerns rj. Antimicrob Agents Chemother. 2010 Jul;54(7):3011-4. doi: 10.1128/AAC.00190-10. Epub 2010 Apr 19. Antimicrob Agents Chemother. 2010. PMID: 20404126 Free PMC article.

6

Synthesis and evaluation of 1-cyclopropyl-2-thioalkyl-8-methoxy fluoroquinolones.

Marks KR, Malik M, Mustaev A, Hiasa H, Drlica K, Kerns RJ. Marks KR, et al. Among authors: kerns rj. Bioorg Med Chem Lett. 2011 Aug 1;21(15):4585-8. doi: 10.1016/j.bmcl.2011.05.112. Epub 2011 Jun 6. Bioorg Med Chem Lett. 2011. PMID: 21705218 Free PMC article.

7

Synthesis, separation, and characterization of amphiphilic sulfated oligosaccharides enabled by reversed-phase ion pairing LC and LC-MS methods.

Fenner AM, Kerns RJ. Fenner AM, et al. Among authors: kerns rj. Carbohydr Res. 2011 Dec 13;346(17):2792-800. doi: 10.1016/j.carres.2011.09.020. Epub 2011 Sep 24. Carbohydr Res. 2011. PMID: 22015170 Free PMC article.

8

Bioenergetic effects of mitochondrial-targeted coenzyme Q analogs in endothelial cells.

Fink BD, Herlein JA, Yorek MA, Fenner AM, Kerns RJ, Sivitz WI. Fink BD, et al. Among authors: kerns rj. J Pharmacol Exp Ther. 2012 Sep;342(3):709-19. doi: 10.1124/jpet.112.195586. Epub 2012 Jun 1. J Pharmacol Exp Ther. 2012. PMID: 22661629 Free PMC article.

9

Fluoroquinolone-gyrase-DNA complexes: two modes of drug binding.

Mustaev A, Malik M, Zhao X, Kurepina N, Luan G, Oppegard LM, Hiasa H, Marks KR, Kerns RJ, Berger JM, Drlica K. Mustaev A, et al. Among authors: kerns rj. J Biol Chem. 2014 May 2;289(18):12300-12. doi: 10.1074/jbc.M113.529164. Epub 2014 Feb 4. J Biol Chem. 2014. PMID: 24497635 Free PMC article.

10

Fluoroquinolones stimulate the DNA cleavage activity of topoisomerase IV by promoting the binding of Mg(2+) to the second metal binding site.

Oppegard LM, Schwanz HA, Towle TR, Kerns RJ, Hiasa H. Oppegard LM, et al. Among authors: kerns rj. Biochim Biophys Acta. 2016 Mar;1860(3):569-75. doi: 10.1016/j.bbagen.2015.12.019. Epub 2015 Dec 23. Biochim Biophys Acta. 2016. PMID: 26723176 Free PMC article.

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