Oppegard LM - Search Results

1

Selective inhibition of bacterial and human topoisomerases by N-arylacyl O-sulfonated aminoglycoside derivatives.

Fenner AM, Oppegard LM, Hiasa H, Kerns RJ. Fenner AM, et al. Among authors: oppegard lm. ACS Med Chem Lett. 2013 May 9;4(5):470-474. doi: 10.1021/ml3004507. ACS Med Chem Lett. 2013. PMID: 23814643 Free PMC article.

2

Design, synthesis, and evaluation of novel N-1 fluoroquinolone derivatives: Probing for binding contact with the active site tyrosine of gyrase.

Towle TR, Kulkarni CA, Oppegard LM, Williams BP, Picha TA, Hiasa H, Kerns RJ. Towle TR, et al. Among authors: oppegard lm. Bioorg Med Chem Lett. 2018 Jun 1;28(10):1903-1910. doi: 10.1016/j.bmcl.2018.03.085. Epub 2018 Mar 30. Bioorg Med Chem Lett. 2018. PMID: 29661533 Free PMC article.

3

Flavone-based analogues inspired by the natural product simocyclinone D8 as DNA gyrase inhibitors.

Verghese J, Nguyen T, Oppegard LM, Seivert LM, Hiasa H, Ellis KC. Verghese J, et al. Among authors: oppegard lm. Bioorg Med Chem Lett. 2013 Nov 1;23(21):5874-7. doi: 10.1016/j.bmcl.2013.08.094. Epub 2013 Sep 5. Bioorg Med Chem Lett. 2013. PMID: 24060488

4

Fluoroquinolones stimulate the DNA cleavage activity of topoisomerase IV by promoting the binding of Mg(2+) to the second metal binding site.

Oppegard LM, Schwanz HA, Towle TR, Kerns RJ, Hiasa H. Oppegard LM, et al. Biochim Biophys Acta. 2016 Mar;1860(3):569-75. doi: 10.1016/j.bbagen.2015.12.019. Epub 2015 Dec 23. Biochim Biophys Acta. 2016. PMID: 26723176 Free PMC article.

5

Novel N-1 substituted fluoroquinolones inhibit human topoisomerase I activity and exhibit anti-proliferative activity.

Oppegard LM, Delgado JL, Kulkarni CA, Towle TR, Hart DE, Williams BP, Lentz SRC, Norris BJ, Flory CM, Schumacher RJ, Murry DJ, Kerns RJ, Hiasa H. Oppegard LM, et al. Invest New Drugs. 2019 Apr;37(2):378-383. doi: 10.1007/s10637-018-0666-x. Epub 2018 Sep 10. Invest New Drugs. 2019. PMID: 30198058 Free PMC article.

6

The C7-aminomethylpyrrolidine group rescues the activity of a thio-fluoroquinolone.

Lentz SRC, Chheda PR, Oppegard LM, Towle TR, Kerns RJ, Hiasa H. Lentz SRC, et al. Among authors: oppegard lm. Biochimie. 2019 May;160:24-27. doi: 10.1016/j.biochi.2019.02.002. Epub 2019 Feb 11. Biochimie. 2019. PMID: 30763638 Free PMC article.

7

Suppression of gyrase-mediated resistance by C7 aryl fluoroquinolones.

Malik M, Mustaev A, Schwanz HA, Luan G, Shah N, Oppegard LM, de Souza EC, Hiasa H, Zhao X, Kerns RJ, Drlica K. Malik M, et al. Among authors: oppegard lm. Nucleic Acids Res. 2016 Apr 20;44(7):3304-16. doi: 10.1093/nar/gkw161. Epub 2016 Mar 16. Nucleic Acids Res. 2016. PMID: 26984528 Free PMC article.

8

Inhibition of human topoisomerases I and II by simocyclinone D8.

Oppegard LM, Nguyen T, Ellis KC, Hiasa H. Oppegard LM, et al. J Nat Prod. 2012 Aug 24;75(8):1485-9. doi: 10.1021/np300299y. Epub 2012 Aug 6. J Nat Prod. 2012. PMID: 22867097

9

Fluoroquinolone-gyrase-DNA complexes: two modes of drug binding.

Mustaev A, Malik M, Zhao X, Kurepina N, Luan G, Oppegard LM, Hiasa H, Marks KR, Kerns RJ, Berger JM, Drlica K. Mustaev A, et al. Among authors: oppegard lm. J Biol Chem. 2014 May 2;289(18):12300-12. doi: 10.1074/jbc.M113.529164. Epub 2014 Feb 4. J Biol Chem. 2014. PMID: 24497635 Free PMC article.

10

Comparison of in vitro activities of fluoroquinolone-like 2,4- and 1,3-diones.

Oppegard LM, Streck KR, Rosen JD, Schwanz HA, Drlica K, Kerns RJ, Hiasa H. Oppegard LM, et al. Antimicrob Agents Chemother. 2010 Jul;54(7):3011-4. doi: 10.1128/AAC.00190-10. Epub 2010 Apr 19. Antimicrob Agents Chemother. 2010. PMID: 20404126 Free PMC article.

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