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Discovery of a novel dual fungal CYP51/human 5-lipoxygenase inhibitor: implications for anti-fungal therapy.
PLoS One. 2013 Jun 24;8(6):e65928. doi: 10.1371/journal.pone.0065928. Print 2013.
PLoS One. 2013.
PMID: 23826084
Free PMC article.
Kinetic and structural investigations into the allosteric and pH effect on the substrate specificity of human epithelial 15-lipoxygenase-2.
Joshi N, Hoobler EK, Perry S, Diaz G, Fox B, Holman TR.
Joshi N, et al. Among authors: hoobler ek.
Biochemistry. 2013 Nov 12;52(45):8026-35. doi: 10.1021/bi4010649. Epub 2013 Oct 30.
Biochemistry. 2013.
PMID: 24171444
Free PMC article.
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Discovery of potent and selective inhibitors of human reticulocyte 15-lipoxygenase-1.
Rai G, Kenyon V, Jadhav A, Schultz L, Armstrong M, Jameson JB, Hoobler E, Leister W, Simeonov A, Holman TR, Maloney DJ.
Rai G, et al.
J Med Chem. 2010 Oct 28;53(20):7392-404. doi: 10.1021/jm1008852.
J Med Chem. 2010.
PMID: 20866075
Free PMC article.
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Pseudoperoxidase investigations of hydroperoxides and inhibitors with human lipoxygenases.
Hoobler EK, Holz C, Holman TR.
Hoobler EK, et al.
Bioorg Med Chem. 2013 Jul 1;21(13):3894-9. doi: 10.1016/j.bmc.2013.04.016. Epub 2013 Apr 18.
Bioorg Med Chem. 2013.
PMID: 23669189
Free PMC article.
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Enzymatic Studies of Isoflavonoids as Selective and Potent Inhibitors of Human Leukocyte 5-Lipo-Oxygenase.
Mascayano C, Espinosa V, Sepúlveda-Boza S, Hoobler EK, Perry S, Diaz G, Holman TR.
Mascayano C, et al. Among authors: hoobler ek.
Chem Biol Drug Des. 2015 Jul;86(1):114-21. doi: 10.1111/cbdd.12469. Epub 2014 Nov 28.
Chem Biol Drug Des. 2015.
PMID: 25359714
Free PMC article.
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Using enzyme assays to evaluate the structure and bioactivity of sponge-derived meroterpenes.
Robinson SJ, Hoobler EK, Riener M, Loveridge ST, Tenney K, Valeriote FA, Holman TR, Crews P.
Robinson SJ, et al. Among authors: hoobler ek.
J Nat Prod. 2009 Oct;72(10):1857-63. doi: 10.1021/np900465e.
J Nat Prod. 2009.
PMID: 19848434
Free PMC article.
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In vitro study of isoflavones and isoflavans as potent inhibitors of human 12- and 15-lipoxygenases.
Mascayano C, Espinosa V, Sepúlveda-Boza S, Hoobler EK, Perry S.
Mascayano C, et al. Among authors: hoobler ek.
Chem Biol Drug Des. 2013 Sep;82(3):317-25. doi: 10.1111/cbdd.12157. Epub 2013 Jun 29.
Chem Biol Drug Des. 2013.
PMID: 23663316
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